Relationship between thyroid hormones and metabolic syndrome in a normal thyroid function population in Western China:a cross-sectional study based on both epidemiological and genetic analysis  

作　　者：Shengru Liang Jing Cai Yang Yang Lei Zhang Peter Taylor Jie Ming Xinwen Yu Ruofan Hu Jie Zhou Colin M.Da-Yan Qiuhe Ji 

机构地区：[1]Department of Endocrinology,Xijing Hospital,Air Force Medical University,Xi'an,Shaanxi 710032,China [2]College of Basic Medicine,Shaanxi University of Chinese Medicine,Xianyang,Shaanxi 712046,China [3]The 986th Hospital of Chinese People's Liberation Army,Xi'an,Shaanxi 710054,China [4]School of Medicine,Cardiff University,Heath Park,Cardiff CF144XN,UK

出　　处：《Chinese Medical Journal》2022年第3期350-352,共3页中华医学杂志（英文版）

基　　金：This work was supported by grants from the National Natural Science Foundation of China(No.81873639);the Chinese Medical Association Foundation and Chinese Diabetes Society,the Key R&D Program of Shaanxi Province(Nos.2017ZDCXLSF0201 and S2020-JC-ZD-004);the National Key R&D Program of China(No.2017YFC1309803);the Key projects of Natural Science Foundation of Shaanxi Province,China(No.S2020-JC-ZD-0042)。

摘　　要：To the Editor:Metabolic syndrome(MetS)is defined as a set of metabolic disorders including abdominal obesity,hyperglycemia,hypertension,and dyslipidemia.[1]As thyroid hormones are essential for cellular energy homeostasis and regulation,the levels of serum thyroid hormones are considered to be associated with various metabolic parameters.Over the past decade,the association between thyroid hormones and MetS has been extensively studied in euthyroid subjects,leading to inconsistent results.Some studies suggested that a high level of thyrotropin(TSH)contributed to the increased incidence of MetS or unfavorable metabolic parameters,whereas other studies found no such correlation.Moreover,some researches have shown that free thyroxin(FT4)levels were inversely proportional to various unfavorable metabolic parameters or MetS,while other studies suggested that FT4 levels have no such association or even a positive association with some unfavorable metabolic components after adjustment.These conflicting results may result from different designs,settings,race,exclusion criteria,adjustments,statistical analyses,and definitions of MetS and population iodine intake.Based on these,our study aimed to evaluate the association and causal relationship between thyroid hormones and MetS in people with normal thyroid function through standard epidemiological and Mendelian randomization analysis.

关 键 词：HOMEOSTASIS function sectional 

分 类 号：R589[医药卫生—内分泌]