鞘磷脂酶在肝细胞癌中的作用  

Role of sphingomyelinases in hepatocellular carcinoma

作　　者：姚春[1] 张广发 乐滢玉 毛德文[2] 张荣臻[2] 刘茵[2] YAO Chun;ZHANG Guangfa;LE Yingyu;MAO Dewen;ZHANG Rongzhen;LIU Yin(Graduate School,Guangxi University of Chinese Medicine,Nanning 530222,China;First Ward of Hepatology,The First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning 530023,China)

机构地区：[1]广西中医药大学研究生院,南宁530222 [2]广西中医药大学第一附属医院肝病一区,南宁530023

出　　处：《临床肝胆病杂志》2022年第2期461-465,共5页Journal of Clinical Hepatology

基　　金：国家自然科学基金面上项目(81774236);国家自然科学基金项目(81960841)。

摘　　要：鞘磷脂酶(SMase)是调节鞘磷脂类信号通路及其相关产物代谢的主要酶类,参与了鞘磷脂复杂代谢过程中的关键步骤。近年来,许多研究表明SMase参与了细胞周期停滞、细胞迁移和炎症等生物学过程,并通过调节肿瘤干细胞的凋亡和增殖来促进肝细胞癌的发生发展。SMase在肝细胞癌的发生发展及诊疗中具有重要潜在生物学价值。就SMase在肝细胞癌发生发展中的作用进行归纳和探讨,以期为其临床治疗和新型药物的开发提供新的思路和策略。Sphingomyelinases(SMase)are the main enzymes that regulate the signaling pathway of sphingomyelin and the metabolism of related products,and they are involved in the key steps of the complex metabolic process of sphingomyelin.In recent years,many studies have shown that SMase is involved in the biological processes such as cell cycle arrest,cell migration,and inflammation and promotes the development and progression of hepatocellular carcinoma by regulating the apoptosis and proliferation of tumor stem cells.SMase has an important potential biological value in the development,progression,diagnosis,and treatment of hepatocellular carcinoma.This article summarizes the exact role of SMase in the development and progression of hepatocellular carcinoma,in order to provide new ideas and strategies for the clinical treatment of hepatocellular carcinoma and the development of new drugs.

关 键 词：癌 肝细胞 鞘脂类 神经酰胺类 

分 类 号：R735.7[医药卫生—肿瘤]