水飞蓟宾联合复方二氯醋酸二异丙胺对非酒精性脂肪肝患者肝功能及血脂水平的影响  

Effects of silybin combined with compound diisopropylamine dichloroacetate on liver function and blood lipid levels in patients with non-alcoholic fatty liver

作　　者：蔡琳 CAI Lin(Department of Infectious Diseases,Wafangdian Central Hospital,Liaoning Province,Wafangdian 116300,China)

机构地区：[1]辽宁省瓦房店市中心医院感染性疾病科,116300

出　　处：《临床合理用药杂志》2022年第5期24-26,共3页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的观察水飞蓟宾联合复方二氯醋酸二异丙胺(CDD)对非酒精性脂肪肝(NAFLD)患者肝功能及血脂水平的影响。方法选取2015年2月-2020年5月辽宁省瓦房店市中心医院收治的NAFLD患者154例,按随机数字表法分为观察组和对照组,各77例。对照组实施CDD治疗,观察组在对照组的基础上联合水飞蓟宾治疗,2组均治疗2个月。比较2组临床疗效,治疗前后肝功能指标、血脂指标及不良反应。结果观察组患者的总有效率为97.40%,高于对照组的88.31%(χ^(2)=4.797,P=0.029);治疗2个月后,2组患者门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、总胆固醇(TC)和三酰甘油(TG)水平均低于治疗前,且观察组低于对照组(P <0.01);观察组患者不良反应总发生率为5.19%,对照组患者不良反应总发生率为3.90%,2组比较差异无统计学意义(χ^(2)=0.194,P=0.659)。结论水飞蓟宾联合CDD治疗NAFLD的疗效较好,可改善患者肝功能及血脂水平,且安全性较高,值得临床推广应用。Objective To observe the effects of silybin combined with compound diisopropylamine dichloroacetate( CDD) on liver function and blood lipid levels in patients with non-alcoholic fatty liver( NAFLD).Methods 154 NAFLD patients admitted to Wafangdian Central Hospital,Liaoning Province from February 2015 to May 2020 were selected,according to the random number table method,they were divided into observation group and control group with 77 cases each.The control group was treated with CDD,and the observation group was treated with silybin on the basis of the control group,both groups were treated for 2 months.Compared the clinical efficacy,liver function indexes,blood lipid indexes before and after treatment and adverse reactions of the two groups.Results The total effective rate of patients in the observation group was97.40%,which was higher than 88.31% in the control group( χ^(2)= 4.797,P = 0.029);After 2 months of treatment,the levels of aspartate aminotransferase( AST),alanine aminotransferase( ALT),total cholesterol( TC) and triacylglycerol( TG)in the two groups were lower than before treatment,and the observation group was lower than the control group( P < 0.01);The total incidence of adverse reactions in the observation group was 5.19%,and the total incidence of adverse reactions in the control group was 3.90%,there was no significant difference between the two groups( χ^(2)= 0.194,P = 0.659).Conclusion Silybin combined with CDD has a better therapeutic effect on NAFLD,can improve the liver function and blood lipid level of patients,and has high safety,which is worthy of clinical application.

关 键 词：非酒精性脂肪肝 水飞蓟宾 复方二氯醋酸二异丙胺 肝功能 血脂 

分 类 号：R575.5[医药卫生—消化系统]