山东省自然人群梅毒血清阳性率及影响因素分析  

Seroprevalence and risk factors of syphilis infection among general population in Shandong Province,China

作　　者：朱佳明 槐鹏程 李富容[1] 潘晴[1] 李珍[1] 于功奇[1] 付希安[1] 刘健[1] 张福仁[1] ZHU Jiaming;HUAI Pengcheng;LI Furong;PAN Qing;LI Zhen;YU Gongqi;FU Xi an;LIU Jian;ZHANG Furen(Shandong Provincial Hospital for Skin Diseases&Shandong Provincial Institute of Dermatology and Venereology,Shandong First Medical University&Shandong Academy of Medical Sciences,Jinan 250022,China)

机构地区：[1]山东第一医科大学附属皮肤病医院(山东省皮肤病医院),山东省皮肤病性病防治研究所,济南250022

出　　处：《中国麻风皮肤病杂志》2022年第5期273-279,共7页China Journal of Leprosy and Skin Diseases

基　　金：山东省重点研发计划(重大科技创新工程)项目(编号:2021LCZX07)。

摘　　要：目的:了解山东省自然人群梅毒血清阳性率及影响因素并对梅毒网络报告数据质量进行评估。方法:采用多阶段复杂抽样法选择全省12个县(市、区)年龄为18~49岁的常住人口共8074人。收集梅毒感染的社会人口学特征及其影响因素,采用单因素和多因素回归分析梅毒感染的危险因素。估算山东省自然人群梅毒发病率并与传染病网络直报系统中梅毒数据进行比较。结果:本研究共纳入有效样本7256份,梅毒血清阳性例数为23例,梅毒血清阳性率为0.30%(95%CI 0.06%~0.53%)。其中鲁东地区梅毒血清阳性率为0.77%(95%CI 0.67%~0.86%),是其它地区的1.71~11.00倍;城镇居民梅毒血清阳性率为0.47%(95%CI 0.19%~0.74%),是农村居民的6.71倍。多因素logistic回归分析显示,居住地为城镇(a OR=6.67,95%CI 1.59~25.00)、职业为农民工(a OR=4.81,95%CI 2.78~8.31)、过去一年家庭人均月收入>1000元(a OR=10.51,95%CI 2.28~48.39)、饮酒间隔时间≤7天(a OR=2.66,95%CI 1.07~6.59)、不知道安全套的使用方法(a OR=2.19,95%CI 1.17~4.11)、过去一年去过娱乐场所(a OR=1.94,95%CI 1.31~2.87)和过去一年新性伴的个数≥2个(a OR=5.63,95%CI 1.14~27.86)是梅毒感染的危险因素。估算山东省自然人群梅毒发病率为41.32/10^(5),是报告发病率(15.46/10^(5))的2.67倍(95%CI 1.91~4.42)。结论:山东省梅毒防治应以鲁东地区和城镇居民为重点,对农民工、文化程度较低、酗酒、经常出入娱乐场所及多性伴人群也应重点关注。梅毒报告发病率低于实际水平,仍需进一步加强医疗机构的梅毒报告管理。Objective:To explore the seroprevalence and risk factors of syphilis infection among general population in Shandong Province,China,and to evaluate the data of syphilis report in shandong province infectious disease network direct reporting system.Methods:A total of 8074 general population aged 18~49 in 12 counties and districts were selected by multi-stage complex sampling.The sociodemographic characteristics and risk factors of syphilis infection were collected.The risk factors of syphilis infection were analyzed using univariate and multivariate regression.The incidence of syphilis in the general population in Shandong was estimated and compared with the syphilis data in the infectious disease Network direct reporting system.Results:A total of 7256 valid samples were included in this study.23 cases were seropositive for syphilis,and the syphilis serum positivity rate was 0.30%(95%CI 0.06%-0.53%).The positive rate of serum syphilis in Ludong district was 0.77%(95%CI 0.67%-0.86%),which was 1.71-11.00 times higher than that in other areas.The positivity rate of syphilis in urban residents was 0.47%(95%CI 0.19%-0.74%),6.71 times higher than that rural residents.Multivariate logistic regression analysis showed that the risk factors for syphilis infection were living in urban areas(a OR=6.67,95%CI 1.59-25.00),migrant workers(a OR=4.81,95%CI 2.78-8.31),the per capita monthly income of the family in the past year was>1000 yuan(a OR=10.51,95%CI 2.28-48.39),the interval between drinking less than 7 days(a OR=2.66,95%CI 1.07-6.59),no knowledge of condom use(a OR=2.19,95%CI 1.17-4.11),visited entertainment place in the past year(a OR=1.94,95%CI 1.31-2.87)and the number of new sexual partners in the past year more than 2(a OR=5.63,95%CI 1.14-27.86).The estimated incidence of syphilis in the general population of Shandong Province was 41.32/10^(5),which 2.67 times(95%CI 1.91-4.42)higher than the reported incidence(15.46/10^(5)).Conclusion:The prevention and treatment of syphilis in Shandong Province should focus on the easte

关 键 词：梅毒 血清阳性率 影响因素 自然人群 

分 类 号：R759.1[医药卫生—皮肤病学与性病学]