白细胞介素-2新型突变蛋白在炎症性肠病治疗中的价值  

Value of interleukin-2 mutein in the treatment of inflammatory bowel disease

作　　者：王二嫚 刘占举[1] Wang Erman;Liu Zhanju(Department of Gastroenterology and Hepatology,Shanghai Tenth People′s Hospital,Tongji University,Shanghai 200072,China)

机构地区：[1]同济大学附属第十人民医院消化内科,上海200072

出　　处：《中华炎性肠病杂志（中英文）》2022年第1期79-82,共4页Chinese Journal of Inflammatory Bowel Diseases

摘　　要：白细胞介素(IL)-2在免疫调节中具有双重作用,一方面可作用于效应细胞激活免疫反应,另一方面可作用于调节性T细胞发挥免疫抑制作用,因此成为炎症性肠病和自身免疫性疾病的治疗靶点之一。低剂量的IL-2已用于某些炎性和自身免疫性疾病的治疗,但因其不良反应限制了IL-2在临床上的应用。为了提高IL-2疗效减少不良反应,目前利用基因工程技术合成了多种IL-2突变蛋白,为IL-2在炎症性肠病和自身免疫性疾病中的应用提供了新的可能。Interleukin(IL)-2 plays a dual role in immune regulation.On one hand,it can activate immune response by regulating effector cells.On the other hand,it can act on regulatory T cells to exert immunosuppressive effect.Therefore,IL-2 has become one of the therapeutic targets of inflammatory and autoimmune diseases.Low dose of IL-2 has been used in the treatment of some inflammatory and autoimmune diseases,but its side effects limit its clinical application.In order to improve the therapeutic effect of IL-2 and reduce the side effects,IL-2 mutant protein has been synthesized by genetic engineering technology,which provides a new possibility for the application of IL-2 in inflammatory and autoimmune diseases.

关 键 词：白细胞介素-2 突变蛋白 炎性和自身免疫性疾病 

分 类 号：R574[医药卫生—消化系统]