易感基因-潘氏细胞-肠道微生态轴在炎症性肠病中的作用  

Role of axis of susceptible genes-paneth cells-intestinal microecology in inflammatory bowel disease

作　　者：徐鹏飞 周千惠 廖雨晗 庄文涵 庄奇 叶月芳[1,2] Xu Pengfei;Zhou Qianhui;Liao Yuhan;Zhuang Wenhan;Zhuang Qi;Ye Yuefang(Department of Clinical Medicine,School of Medicine,Hangzhou Normal University,Hangzhou 311121,China;Department of Gastroenterology,the Affiliated Hospital of Hangzhou Normal University,Hangzhou 310015,China)

机构地区：[1]杭州师范大学医学部临床医学院,杭州311121 [2]杭州师范大学附属医院消化内科,杭州310015

出　　处：《中华炎性肠病杂志（中英文）》2022年第1期83-86,共4页Chinese Journal of Inflammatory Bowel Diseases

基　　金：浙江省自然科学基金项目(LY16H030017);高层次留学回国人员在杭创新项目;杭州师范大学2020年“星光计划”学生创新项目;2021年浙江省大学生科技创新活动计划暨新苗人才计划项目。

摘　　要：炎症性肠病(IBD)是由环境因素作用于遗传易感人群,导致的免疫系统和肠道微生态系统失调的疾病。潘氏细胞(PC)在IBD发病过程中,尤其是在克罗恩病发展过程中处于中心地位,其形态、数量、功能容易受易感基因的影响而发生改变。在肠道中,PC通过分泌抗菌颗粒,参与构成干细胞微环境,起到调节肠道微生态和维持肠道黏膜稳态的作用,同时PC的增殖和成熟又是依赖于肠道中的共生菌群。本文介绍易感基因、PC、肠道微生态三者之间的相互作用以及对IBD发生发展的影响。Inflammatory bowel disease(IBD)is a disorder of immune and microbial dysregulation,induced by environmental factors in a genetically predisposed individual.Studies on IBD-associated genes have demonstrated that Paneth cells(PC)are central to the pathogenesis of IBD,especially in the development of Crohn′s disease(CD).The morphology,quantity and function of PC are easily affected by susceptible genes.In the intestine,PC participate in the formation of stem cell niche and secrete antimicrobial particles,which plays a vital role in regulating intestinal microbiota and maintaining intestinal mucosal homeostasis.Meanwhile,the proliferation and maturation of PC are also dependent on the symbiotic microbiota in the intestine.This review focuses on the interaction of susceptible genes,PC and intestinal microbiota,as well as their influence on the occurrence and development of IBD.

关 键 词：潘氏细胞 炎症性肠病 肠道菌群 易感基因 

分 类 号：R574[医药卫生—消化系统]