新型冠状病毒(SARS-CoV-2)变异的研究进展  

Research progress on the mutation of SARS-CoV-2

作　　者：蒋潘虹 阮嘉雯 俞慕华[2] 卢次勇[1] JIANG Pan-hong;RUAN Jia-wen;YU Mu-hua;LU Ci-yong(School of Public Health,Sun Yat-sen University,Guangzhou 510030,China;Nanshan Center for Disease Control and Prevention,Shenzhen 518051,China)

机构地区：[1]中山大学公共卫生学院,广州510030 [2]深圳市南山区疾病预防控制中心,深圳518051

出　　处：《中国人兽共患病学报》2022年第2期157-164,共8页Chinese Journal of Zoonoses

基　　金：深圳市“医疗卫生三名工程”引进高层次医学团队项目(No.SZSM201803081);深圳市南山区2020年科技计划项目(医疗卫生类);深圳市南山区医学重点学科项目(病原生物学)联合资助。

摘　　要：2019年12月底,湖北省武汉市暴发了由新型冠状病毒(SARS-CoV-2)引起的肺炎疫情。迄今为止,该病毒引起的疫情仍在全球流行,累计感染人数超1.8亿。随着SARS-CoV-2在人群间的不断传播,其基因组不断发生变异,从SARS-CoV-2首次出现S蛋白D614G突变到被世界卫生组织列为关切的Alpha、Beta、Gamma、Delta突变株以及其他一些受关注的突变株。新变异株的不断出现,引起大众广泛的关注。因此本文将从SARS-CoV-2的基因组结构及功能、国际上主要流行的变异株的一些特点、SARS-CoV-2疫苗对变异株保护结果以及应对SARS-CoV-2变异的疫苗策略等方面进行简要概述。At the end of December 2019,an outbreak of pneumonia caused by SARS-CoV-2 occurred in Wuhan,Hubei Province.So far,the epidemic caused by the virus is still circulating globally,infecting more than 180 million people in total.With the continuous spread of SARS-CoV-2 among populations,its genome has continued to mutate,from the first discovery of D614 G mutation of the S protein in SARS-CoV-2 to Alpha,Beta,Gamma,Delta listed as concerns by the World Health Organization and some other variants of interest.The continuous emergence of new variants has aroused widespread public concern.Therefore,this article will briefly summarize the genome structure and function of SARS-CoV-2,some of the characteristics of the main international variants,the protection results of SARS-CoV-2 vaccines against the variants,and the vaccine strategies to deal with SARS-CoV-2 mutations.

关 键 词：新型冠状病毒肺炎 新型冠状病毒 突变 

分 类 号：R373.1[医药卫生—病原生物学]