TCD评估丁苯酞改善大脑中动脉闭塞导致的脑梗死后侧支代偿能力研究  

TCD Evaluation of Butylphthalide to Improve Collateral Compensation after Cerebral Infarction Caused by Middle Cerebral Artery Occlusion

作　　者：郭嘉英 贾龙斌 GUO Jiaying;JIA Longbin(Department of Neurology,Jincheng People's Hospital,Jincheng,Shanxi Province,048000 China)

机构地区：[1]晋城市人民医院神经内科,山西晋城048000

出　　处：《世界复合医学》2021年第12期83-85,127,共4页World Journal of Complex Medicine

摘　　要：目的浅析经颅多普勒超声(transcranial Doppler,TCD)评估丁苯酞治疗大脑中动脉(MCA)主干闭塞所致急性脑梗死患者的侧支改善能力。方法选取该院2017年7月—2019年12月收治的单侧MCA主干闭塞导致的急性脑梗死患者60例作为研究对象,均行磁共振成像(magnetic resonance imaging,MRI)、磁共振血管造影(magnetic resonance angiography,MRA)、TCD检查,再根据数字表法随机分为对照组与研究组,各30例,对照组接受常规治疗,研究组在常规治疗基础上加用丁苯酞治疗,就患者治疗两周前后的脑血流动力学参数进行比较分析。结果两组患者治疗两周后MCA峰值流速均在一定程度上增高,研究组MCA(53.65±3.62)cm/s、ACA(143.54±4.52)cm/s、PCA(92.64±3.17)cm/s均高于对照组,差异有统计学意义(t=3.424、3.961、3.494,P<0.05);两组患者治疗两周后RVACA、RVPCA均在一定程度上增高,且研究组PVACA(1.60±0.08)、RVPCA(1.61±0.04)增加幅度高于对照组,差异有统计学意义(t=8.709、11.120,P<0.05)。结论丁苯酞可以改善MCA闭塞患者侧支代偿状况;TCD可作为对MCA闭塞患者侧支代偿情况的有效评估工具。Objective To analyze the ability of Transcranial Doppler(TCD) to evaluate the ability of butylphthalide in the treatment of patients with acute cerebral infarction caused by Middle Cerebral Artery(MCA) main stem occlusion.Methods A total of 60 patients with acute cerebral infarction caused by unilateral MCA trunk occlusion admitted to the hospital from July 2017 to December 2019 were selected as the research objects.All were examined by Magnetic Resonance Imaging(MRI),Magnetic Resonance Angiography(MRA),and TCD.According to the digital table method,they were randomly divided into the control group and the study group,each with 30 cases.The control group received conventional treatment,and the study group was treated with butylphthalide on the basis of conventional treatment.The cerebral hemodynamic parameters of patients before and after 2 weeks of treatment were compared and analyzed.Results The peak flow velocity of MCA increased to a certain extent after 2 weeks of treatment in both groups.MCA(53.65±3.62) cm/s,ACA(143.54±4.52) cm/s,and PCA(92.64±3.17) cm/s in the study group were all increased,higher than the control group,and the difference was statistically significant(t=3.424,3.961,3.494,P<0.05).The RVACA and RVPCA of the two groups of patients increased to a certain extent after 2 weeks of treatment.And the increase of PVACA(1.60±0.08) and RVPCA(1.61±0.04)in the study group was higher than that in the control group,and the difference was statistically significant(t=8.709,11.120,P<0.05).Conclusion Butylphthalide can improve the collateral compensation of patients with MCA occlusion.TCD can be used as an effective assessment tool for collateral compensation in patients with MCA occlusion.

关 键 词：丁苯酞 经颅多普勒超声 动脉闭塞 脑梗死 

分 类 号：R743[医药卫生—神经病学与精神病学]