生长抑素与参芎葡萄糖注射液联合应用治疗胰腺炎的临床效果探讨  

The Clinical Effect of Somatostatin and Shenxiong Glucose Injection in the Treatment of Pancreatitis

作　　者：刘国良 蒋丹斌[1] LIU Guoliang;JIANG Danbin(Department of Gastroenterology,the Third People's Hospital of Yancheng(Yancheng Clinical School of Nanjing Medical University),Yancheng,Jiangsu Province,224000 China)

机构地区：[1]江苏省盐城市第三人民医院(南京医科大学盐城临床医学院)消化内科,江苏盐城224000

出　　处：《世界复合医学》2021年第12期132-135,共4页World Journal of Complex Medicine

摘　　要：目的观察生长抑素与参芎葡萄糖注射液联合应用治疗急性胰腺炎的临床效果。方法该研究涉及对象为盐城市第三人民医院消化内科于2017年1月—2020年12月收治的急性胰腺炎患者80例,以随机抽签法分为对照组、观察组,每组40例。对照组在常规治疗的基础上使用生长抑素,观察组则在对照组基础上加入参芎葡萄糖注射液,对比两组炎性因子控制质量、氧化应激指标以及肠道黏膜屏障功能。结果治疗前观察组TNF-α、IL-6以及CRP指标与对照组对比差异无统计学意义(t=0.164、0.104、0.028,P>0.05),治疗后观察组TNF-α(21.65±2.34)μg/L、IL-6(17.64±1.12)μg/L、CRP(13.66±6.21)mg/L均低于对照组,差异有统计学意义(t=38.929、41.493、6.218,P<0.001);治疗前两组氧化应激指标对比差异无统计学意义(t=0.143、0.718、0.095,P>0.05),治疗后观察组MDA低于对照组,SOD、GSH-Px高于对照组,差异有统计学意义(P<0.001);治疗前两组肠道黏膜屏障功能指标对比差异无统计学意义(t=0.035、0.039、0.028,P>0.05),治疗后观察组PE、DAO、UA-MY低于对照组,差异有统计学意义(P<0.001)。结论急性胰腺炎的治疗中联合使用生长抑素与参芎葡萄糖注射液可更加有效地缓解临床症状,及时控制体内炎性因子,改善氧化应激反应,对于肠道黏膜屏障功能的提升具有积极作用,对于疾病的治疗更加有利,值得临床推广普及。Objective To observe the clinical effect of somatostatin combined with Shenxiong Glucose Injection in the treatment of acute pancreatitis.Methods The study involved 80 patients with acute pancreatitis admitted to department of Gastroenterology,Yancheng Third People’s Hospital from January 2017 to December 2020.They were divided into control group and observation group by random drawing,with 40 cases in each group.The control group used somatostation on the basis of routine treatment.The observation group was added Shenxiong Glucose Injection on the basis of the control group,and the therapeutic effect,inflammatory factor control quality,oxidative stress index and intestinal mucosal barrier function were compared between the two groups.Results Before treatment,there were no statistically significant differences in TNF-α,IL-6 and CRP between the observation group and the control group(t=0.164,0.104,0.028,P>0.05).After treatment,TNF-α(21.65±2.34) μg/L,IL-6(17.64±1.12) μg/L and CRP(13.66±6.21) mg/L in the observation group were lower than those in the control group,and the differences were statistically significant(t=38.929,41.493,6.218,P<0.001).Before treatment,there was no statistically significant difference in oxidative stress indexes between the two groups(t=0.143,0.718,0.095,P>0.05).After treatment,MDA in the observation group was lower than that in the control group,while SOD and GSH-Px were higher than those in the control group,the difference was statistically significant(P<0.001).Before treatment,there was no statistically significant difference in the intestinal mucosal barrier function indexes between the two groups(t=0.035,0.039,0.028,P>0.05).After treatment,PE,DAO and UA-MY in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.001).Conclusion the treatment of acute pancreatitis combined with somatostatin and Shenxiong Glucose Injection can more effectively relieve clinical symptoms,timely control the body inflammatory factor,imp

关 键 词：生长抑素 参芎葡萄糖注射液 急性胰腺炎 治疗效果 炎性因子 肠道黏膜屏障 

分 类 号：R576[医药卫生—消化系统]