The KiSS-1/GPR54 system:Essential roles in physiological homeostasis and cancer biology  

作　　者：Nisha Zhu Mengxiang Zhao Yuxian Song Liang Ding Yanhong Ni 

机构地区：[1]Central Laboratory of Stomatology,Nanjing Stomatological Hospital,Medical School of Nanjing University,30 Zhongyang Road,Nanjing,Jiangsu 210008,PR China

出　　处：《Genes & Diseases》2022年第1期28-40,共13页基因与疾病（英文）

基　　金：This work was supported by National Natural Science Foundation of China(No.81902754 to LD,81772880 to YN and 81702680 to YS);China Postdoctoral Science Foundation(No.2019M651789 to LD);Fundamental Research Funds for the Central Universities(No.021014380161 to LD);Natural Science Foundation of Jiangsu Province(No.BK20190304 to LD);Nanjing Medical Science and Technology Development Foundation,Nanjing Department of Health(No.YKK17138 to YS).

摘　　要：KiSS-1,first identified as an anti-metastasis gene in melanoma,encodes C-terminally amidated peptide products,including kisspeptin-145,kisspeptin-54,kisspeptin-14,kisspeptin-13 and kisspeptin-10.These products are endogenous ligands coupled to G protein-coupled receptor 54(GPR54)/hOT7T175/AXOR12.To date,the regulatory activities of the KiSS-1/GPR54 system,such as puberty initiation,antitumor metastasis,fertility in adulthood,hypothalamic-pituitary-gonadal axis(HPG axis)feedback,and trophoblast invasion,have been investigated intensively.Accumulating evidence has demonstrated that KiSS-1 played a key role in reproduction and served as a promising biomarker relative to the diagnosis,identification of therapeutic targets and prognosis in various carcinomas,while few studies have systematically summarized its subjective factors and concluded the functions of KiSS-1/GPR54 signaling in physiology homeostasis and cancer biology.In this review,we retrospectively summarized the regulators of the KiSS-1/GPR54 system in different animal models and reviewed its functions according to physiological homeostasis regulations and above all,cancer biology,which provided us with a profound understanding of applying the KiSS-1/GPR54 system into medical applications.

关 键 词：KiSS-1/GPR54 KISSPEPTIN Physiological homeostasis Regulators in vivo and in vitro Tumor metastasis 

分 类 号：R730.2[医药卫生—肿瘤]