急性缺血性脑卒中患者血清FGF4、salusin-α、MCP-1水平的临床价值研究  

The clinical value of serum FGF4,salusin-αand MCP-1 levels in patients with acute ischemic stroke

作　　者：刘盼 刘畅[1] 孙家安 常东歌 Liu Pan;Liu Chang;Sun Jiaan;Chang Dongge(Department of emergency,Zhengzhou central hospital,Zhengzhou,Henan,450007,China)

机构地区：[1]郑州市中心医院急诊科,河南郑州450007

出　　处：《齐齐哈尔医学院学报》2022年第2期105-109,共5页Journal of Qiqihar Medical University

基　　金：2017年河南省医学科技攻关计划项目(2017T02095)。

摘　　要：目的探讨急性缺血性脑卒中(AIS)患者血清成纤维细胞生长因子4(FGF4)、salusin-α蛋白、单核细胞趋化蛋白-1(MCP-1)水平检测的临床价值。方法选择2018年9月—2019年9月本院收治的AIS患者102例作为AIS组,选取同期于本院体检的健康志愿者88名作为健康组,比较两组血清FGF4、salusin-α、MCP-1水平。分别根据美国国立卫生研究院卒中量表(NIHSS)评分、脑梗死体积、改良Rankin量表(mRS)评分进行亚分组,比较不同神经功能缺损程度、脑梗死体积、预后患者的血清FGF4、salusin-α、MCP-1水平,分析上述血清指标与NIHSS评分、mRS评分的相关性。结果AIS组血清FGF4、MCP-1水平高于健康组,血清salusin-α低于健康组(P<0.05)。中度、重度缺损组血清FGF4、MCP-1水平以及NIHSS评分高于轻度缺损组,且重度缺损组高于中度缺损组,而中度、重度缺损组血清salusin-α水平低于轻度缺损组,且重度缺损组低于中度缺损组(P<0.05)。大体积梗死组的血清FGF4、MCP-1水平高于非大体积梗死组,血清salusin-α水平低于非大体积梗死组(P<0.05)。预后不良组血清FGF4、MCP-1水平及mRS评分高于预后良好组,血清salusin-α水平低于预后良好组(P<0.05)。Pearson分析显示血清FGF4、MCP-1水平与NIHSS、mRS评分呈正相关,血清salusin-α水平与NIHSS、mRS评分呈负相关(P<0.05)。结论AIS患者血清FGF4、MCP-1水平明显升高,血清salusin-α水平降低,且血清FGF4、salusin-α、MCP-1水平与患者神经功能缺损程度、脑梗死体积及预后密切相关。Objective To explore the clinical value of serum fibroblast growth factor 4(FGF4),salusin-α,monocyte chemoattractant protein 1(MCP-1)levels in patients with acute ischemic stroke(AIS).Methods A total of 102 patients with AIS those were admitted to our hospital from September 2018 to September 2019 were included as the AIS group,and select 88 healthy volunteers who received physical examination in our hospital during the same period as the healthy group.They were divided into subgroups according to the national institutes of health stroke scale(NIHSS)scores,cerebral infarction volume,and modified Rankin scale(mRS)scores.The levels of serum FGF4,salusin-α,MCP-1 in patients with different degrees of neurological deficit,cerebral infarction volume and prognosis were compared.The correlation between the above serum indicators and NIHSS scores and mRS scores were analyzed.Results The serum FGF4 and MCP-1 levels of the AIS group were higher than those of the healthy group,and the serum salusin-αwas lower than the healthy group(P<0.05).Serum FGF4,MCP-1 and NIHSS scores in the moderate and severe defect groups were higher than those in the mild defect group,and the severe defect group was higher than the moderate defect group,while the serum salusin-αlevel in the moderate and severe defect group was lower than the mild defect group,and the severe defect group was lower than the moderate defect group(P<0.05).The level of serum FGF4 and MCP-1 in the large infarction group was higher than that in the non-large infarction group,and the serum salusin-αlevel was lower than that in the non-large infarction group(P<0.05).The serum FGF4,MCP-1 and mRS scores of the poor prognosis group were higher than those of the good prognosis group,and the serum salusin-αlevel was lower than the good prognosis group(P<0.05).Pearson analysis showed that serum FGF4 and MCP-1 levels were positively correlated with NIHSS and mRS scores,and serum salusin-αwas negatively correlated with NIHSS and mRS scores(P<0.05).Conclusions Serum FGF4 and M

关 键 词：急性 缺血性脑卒中 成纤维细胞生长因子4 salusin-α 单核细胞趋化蛋白-1 预后 

分 类 号：R743.3[医药卫生—神经病学与精神病学]