N-苯基丙烯酰胺与草氨酸衍生物的脱羧氨甲酰化反应研究  

Decarboxylative Amidation of Acrylamides with Oxamic Acids

作　　者：高启升 荆祺 陈阳 孙京 周明东[1] Gao Qisheng;Jing Qi;Chen Yang;Sun Jing;Zhou Mingdong(School of Petrochemical Engineering,Liaoning Petrochemical University,Fushun,Liaoning 113001)

机构地区：[1]辽宁石油化工大学石油化工学院,辽宁抚顺113001

出　　处：《有机化学》2022年第1期257-265,共9页Chinese Journal of Organic Chemistry

基　　金：辽宁省教育厅一般项目基金(No.L2019037)资助项目。

摘　　要：报道了一种银催化的N-苯基丙烯酰胺与N-取代草氨酸类衍生物的脱羧氨甲酰化反应,通过分子间的氨甲酰自由基加成/环化过程,能够以良好的产率制备一系列3,3-二取代的氨甲酰官能化的吲哚酮类化合物.该反应具有广泛的官能团兼容性和良好的底物适用范围.A silver catalyzed decaroxylative amidation of N-arylacrylamides with oxamic acids has been developed.This cascade reaction is an effective way to synthesize various 3,3-disubstitued amide functionalized oxindoles through a sequence of intermolecular carbamoyl radical addition and cyclization in moderate to good yields.This reaction allows a broad range of substrates as well as good functional group compatibility.

关 键 词：氨甲酰化 吲哚酮 自由基加成环化 

分 类 号：O626[理学—有机化学]