蛋白磷酸酶1及其去磷酸化与抑郁症的关联研究  

Relationships between protein phosphatase 1 and its dephosphorylation and depression

作　　者：马相贤 蒋宇婷 王三旺 崔明湖[2] Ma Xiangxian;Jiang Yuting;Wang Sanwang;Cui Minghu(Affiliated Hospital of Binzhou Medical University(First Clinical Medical School of Binzhou Medical University),Binzhou 256600,China;Department of Psychology,Affiliated Hospital of Binzhou Medical University,Binzhou 256699,China)

机构地区：[1]滨州医学院附属医院滨州医学院第一临床医学院,滨州256600 [2]滨州医学院附属医院心理科,滨州256699

出　　处：《国际医药卫生导报》2022年第6期741-744,共4页International Medicine and Health Guidance News

基　　金：国家自然科学基金青年基金(81601189)。

摘　　要：近年来发现蛋白磷酸酶家族在不同的脑区进行的生物调控在抑郁症研究中一直很受重视,其中丝氨酸/苏氨酸蛋白磷酸酶1(proteinphosphatase 1,PP1)可通过其在突触处催化细胞中大部分磷酸丝氨酸和磷酸苏氨酸的去磷酸化来控制突触可塑性。尽管PP1及其去磷酸化参与了许多关键的生物过程,但与抑郁症的相关性研究较少。本文通过综述各种证据,支持PP1及其去磷酸化在抑郁症的发病机制与疾病进展中可能发挥重要的作用。In recent years,it has been found that the biological regulation of protein phosphatase family in different brain regions has attracted much attention in depression research.Serine/Threonine protein phosphatase 1(PP1)controls synaptic plasticity by catalyzing the dephosphorylation of most phosphoserine and phosphothreonine in cells at synapses.Although PP1 and its dephosphorylation are involved in many key biological processes,there is a relative paucity of studies on their relationships with depression.This paper reviews various evidences to support that PP1 and its dephosphorylation may play an important role in the pathogenesis and disease progression of depression.

关 键 词：丝氨酸/苏氨酸蛋白磷酸酶1 去磷酸化 抑郁症 突触可塑性 

分 类 号：R749.4[医药卫生—神经病学与精神病学]