PRF对牙龈退缩患者牙龈状况及龈沟液炎性因子的影响  

The Effect of PRF on Gingival Condition and Inflammatory Factors of Gingival Crevicular Fluid in Patients with Gingival Recession

作　　者：郭建茹[1] 高志强[2] 冯妍 董娜 张春辉[1] GUO Jianru;GAO Zhiqiang;FENG Yan;DONG Na;ZHANG Chunhui(Department of Periodontology,Union Medical College Hospital,Tangshan 063000,Hebei,China;Department of rehabilitation,Union Medical College Hospital,Tangshan 063000,Hebei,China)

机构地区：[1]唐山市协和医院牙周科,河北唐山063000 [2]唐山市协和医院修复科,河北唐山063000

出　　处：《中国美容医学》2022年第2期104-108,共5页Chinese Journal of Aesthetic Medicine

基　　金：河北省2020年度医学科学研究课题计划(编号:20201544)。

摘　　要：目的:探讨富血小板纤维蛋白(Platelet-rich fibrin,PRF)对牙龈退缩(Gingival recession,GR)患者牙龈状况及龈沟液炎性因子的影响。方法:选择2018年1月-2019年10月笔者科室就诊的168例GR患者临床资料进行回顾性研究,根据治疗方法不同分为研究组(n=84,患牙113颗)和对照组(n=84,患牙108颗)。对照组采取上皮下结缔组织瓣移植治疗,研究组采取PRF治疗。比较两组临床疗效、治疗前后GR深度、根面覆盖率、牙龈厚度、临床附着丧失(Clinical attachment loss,CAL)、探诊深度(Probing depth,PD)、出血指数(Bleeding index,BI)、龈沟液炎性因子[白细胞介素-6(Interleukin-6,IL-6)、高敏C反应蛋白(high-sensitivity C-reactive protein,hs-CRP)、IL-1β、肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)]水平、美观效果[视觉模拟评分法(Visual analogue scale,VAS)、粉红美学指数(Pink esthetic score,PES)评分]及治疗满意度。结果:治疗后,研究组总有效率(95.24%)与对照组(92.86%)比较,差异无统计学意义(P>0.05);两组治疗后1个月、6个月GR深度均小于治疗前,牙龈厚度均大于治疗前,差异有统计学意义(P<0.05);两组治疗前,治疗后1个月、6个月根面覆盖率对比,差异均无统计学意义(P>0.05);两组治疗后1个月、6个月BI、PD、CAL均低于治疗前(P<0.05);治疗后1周,研究组龈沟液IL-6、hs-CRP、IL-1β、TNF-α水平均低于对照组,差异有统计学意义(P<0.05);治疗后6个月,研究组VAS及PES评分均高于对照组,研究组治疗满意度(95.24%)高于对照组(85.71%),差异有统计学意义(P<0.05)。结论:采用PRF治疗GR患者能取得与上皮下结缔组织瓣移植相近的显著疗效,能有效减轻患者临床症状,进一步抑制龈沟液炎性因子表达,提高美观效果及患者满意度。Objective To investigate the effect of platelet-rich fibrin (PRF) on gingival conditions and inflammatory factors in gingival crevicular fluid in patients with gingival recession (GR).Methods The clinical data of 168 GR patients in our hospital from January 2018 to October 2019 were selected to conduct a retrospective study,according to different treatment methods,they were divided into study group (n=84,113 teeth) and control group (n=84,108 teeth).The control group was treated with subepithelial connective tissue flap transplantation,and the study group was treated with PRF.The clinical efficacy,GR depth,root coverage,gingival thickness,clinical attachment loss (CAL),and probing depth (PD),bleeding index (BI),gingival crevicular fluid inflammatory factors[interleukin-6 (IL-6),high-sensitivity C-reactive protein (hs-CRP),IL-1β,tumor necrosis factor-α (TNF-α)]levels,aesthetic effects[visual analogue scale (VAS) and pink esthetic score (PES)],and treatment satisfaction were compared between the two groups before and after treatment.Results The total effective rate of the study group (95.24%) was compared with the control group (92.86%),and the difference was not statistically significant (P>0.05).In the two groups,the GR depth at 1 and 6 months after treatment was smaller than before treatment,and the gingival thickness was larger than before treatment (P<0.05).There was no statistically significant difference in the root surface coverage between the two groups before treatment,1 month and 6 months after treatment (P>0.05).The BI,PD,and CAL of the two groups were lower than before treatment at 1 month and 6 months after treatment (P<0.05),the levels of IL-6,hs-CRP,IL-1β and TNF-α in the gingival crevicular fluid of the study group were lower than those of the control group one week after treatment (P<0.05).The VAS and PES scores of the study group were higher than those of the control group 6 months after treatment (P<0.05),the treatment satisfaction of the study group (95.24%) was higher than that of the con

关 键 词：牙龈退缩 富血小板纤维蛋白 牙龈状况 炎性因子 美观效果 

分 类 号：R781.42[医药卫生—口腔医学]