Genetically engineered materials:Proteins and beyond  

作　　者：Jingjing Wei Lianjie Xu Wen-Hao Wu Fei Sun Wen-Bin Zhang 

机构地区：[1]College of Chemical and Environmental Engineering,Anyang Institute of Technology,Anyang 455000 [2]China 2.Beijing National Laboratory for Molecular Sciences,Key Laboratory of Polymer Chemistry&Physics of Ministry of Education,Center for Soft Matter Science and Engineering,College of Chemistry and Molecular Engineering,Peking University,Beijing 100871 [3]China 3.Department of Chemical and Biological Engineering,The Hong Kong University of Science and Technology,Clear Water Bay,Kowloon,Hong Kong SAR,China

出　　处：《Science China Chemistry》2022年第3期486-496,共11页中国科学（化学英文版）

基　　金：supported by the National Natural Science Foundation of China(21905001,21925102,21991132,92056118);the National Key R&D Program of China(2020YFA0908100);Beijing Municipal Natural Science Foundation(L182003);Beijing National Laboratory for Molecular Sciences(BNLMS-CXXM-202006);Guangdong Natural Science Foundation(GDST19EG22);the Science,Technology,and Innovation Commission of Shenzhen Municipality(JCYJ20190813094601656);Clinical Medicine Plus X project of Peking University;Fundamental Research Funds for the Central Universities。

摘　　要：Information-rich molecules provide opportunities for evolution.Genetically engineered materials are superior in that their properties are coded within genetic sequences and could be fine-tuned.In this review,we elaborate the concept of genetically engineered materials(GEMs)using examples ranging from engineered protein materials to engineered living materials.Proteinbased materials are the materials of choice by nature.Recent progress in protein engineering has led to opportunities to tune their sequences for optimal material performance.Proteins also play a central role in living materials where they act in concert with other biological components as well as nonbiological cofactors,giving rise to living features.While the existing GEMs are often limited to those constructed by building blocks of biological origin,being genetically engineerable does not preclude nonbiologic or synthetic materials,the latter of which have yet to be fully explored.

关 键 词：PROTEIN genetic engineering SELF-ASSEMBLY living materials 

分 类 号：TQ931[化学工程]