甲状腺乳头状癌COX-2和SLeX表达临床研究  

Clinical Study of COX-2 and SLeX Expression in Papillary Thyroid Carcinoma

作　　者：聂阿娜 王德淼 胡玮 尚培中[1] 李伟[3] 蒋童新 NIE A-na;WANG De-miao;HU Wei;SHANG Pei-zhong;LI Wei;JIANG Tong-xin(Department of General Surgery,The 81 Group Army Hospital of PLA,Zhangjiakou,Hebei 075000,China;Department of General Surgery,Shiji Hospital of Huailai,Huailai,Hebei 075400,China;Department of Pathological and Medical Laboratory,The 81 Group Army Hospital of PLA,Zhangjiakou,Hebei 075000,China)

机构地区：[1]中国人民解放军陆军第八十一集团军医院普通外科,河北张家口075000 [2]河北怀来世济医院普通外科,河北怀来075400 [3]中国人民解放军陆军第八十一集团军医院检验病理科,河北张家口075000

出　　处：《河北北方学院学报（自然科学版）》2022年第4期5-9,16,共6页Journal of Hebei North University:Natural Science Edition

基　　金：张家口市大健康和生物医疗专项重点研发计划项目(No.2021065D,No.2121100D)。

摘　　要：目的探讨COX-2和SLeX表达与甲状腺乳头状癌(PTC)临床病理指标的关系。方法120例PTC手术切除标本,应用EliVisionTM plus免疫组化两步法检测COX-2和SLeX在癌组织及癌旁甲状腺组织中的表达,分析其在PTC组织中的表达与患者年龄(<45岁与≥45岁)、TI-RADS分类[(4类+5类)与6类]、TNM分期[(T1期+T2期)与T3期]、癌浸润(有、无)、淋巴结转移(有、无)等临床病理指标的关系。结果COX-2阳性染色多见于细胞质,SLeX阳性染色多见于细胞膜和细胞质。癌组织COX-2和SLeX阳性率分别为72.5%和67.5%,癌旁甲状腺组织分别为3.3%和6.7%,差异均有统计学意义(P<0.05)。不同年龄及TI-RADS分类中COX-2阳性率差异无统计学意义(P>0.05),不同TNM分期及是否有癌浸润、淋巴结转移中COX-2阳性率差异有统计学意义(P<0.05)。不同年龄组中SLeX阳性率差异无统计学意义(P>0.05),不同TI-RADS分类、TNM分期及是否有癌浸润、淋巴结转移中SLeX阳性率差异均有统计学意义(P<0.05)。120例患者COX-2和SLeX共阳性率为61.7%,共阴性率为21.7%,两者表达呈正相关(r=0.52,P<0.05)。结论COX-2和SLeX表达均与PTC患者年龄无关,SLeX表达与TI-RADS分类有关,两者表达上调均预示癌组织TNM分期晚,浸润性强,易发生淋巴结转移。Objective To investigate the relationship of COX-2 and SLeX expression in papillary thyroid carcinoma(PTC)between clinicopathologic parameters.Methods A total of 120 patients with PTC underwent resection.The expressions of COX-2 and SLeX were detected in primary PTC tissue and adjacent carcinoma tissue by EliVisionTM plus two-step immunohistochemical method.The relationships between the expressions of COX-2 and SLeX and the clinicopathologic parameters including patient age(<45 years vs.≥45 years),TI-RADS classsification[(classsification 4 and 5)vs.classsification 6],TNM staging[(stage T1 and T2)vs.stage T3],carcinomatous infiltration(with vs.Without)and lymph node metastasis(with vs.Without)were studied.Results COX-2 positive staining was mainly localized in the cytoplasm.SLeX positive staining was mainly localized in cell membrane and cytoplasm.The differences of positive rates of COX-2 and SLeX between primary PTC tissue(72.5%and 67.5%,respectively)and adjacent carcinoma tissue(3.3%and 6.7%,respectively)were statistically significant(P<0.05).The expressions of COX-2 had not statistical significance in the groups of different ages and TI-RADS classsification(P>0.05).The COX-2 expression were significantly correlated with the TNM stages,carcinomatous infiltration,lymph node metastasis(P<0.05).The expressions of SLeX were not statistically significant in the groups of different ages(P>0.05).The SLeX expression were significantly correlated with the TI-RADS classsification,TNM stages,carcinomatous infiltration,lymph node metastasis(P<0.05).The co-positive and co-negative expression rates of COX-2 and SLeX in 120 patients were 61.7%and 21.7%,respectively,with a positive correlation(r=0.52,P<0.05).Conclusion The positive rates of COX-2 and SLeX expressions were not correlated with patient’s age.The positive expression of SLeX was closely correlated with TI-RADS classification.The up-regulation of COX-2 and SLeX expressions predicted higher tumor stage,more aggressive invasion and more prone to lymph node metasta

关 键 词：甲状腺乳头状癌 COX-2 SLEX 肿瘤浸润 肿瘤转移 

分 类 号：R736.1[医药卫生—肿瘤]