胃肠道间质瘤中GNG13的表达及其临床意义  

Expression and clinical significance of GNG13 in gastrointestinal stromal tumors

作　　者：杨珺 施维佳[1] 赵靖[1] 贾宇新 倪辉 YANG Jun;SHI Wei-jia;ZHAO Jing;JIA Yu-xin;NI Hui(Department of Gastroenterology,Liyang Branch of Jiangsu Provincial People’s Hospital/Liyang City People’s Hospital,Liyang 213300,China;School of Basic Medicine,Nanjing Medical University,Nanjing 211166,China)

机构地区：[1]江苏省人民医院溧阳分院/溧阳市人民医院消化内科,溧阳213300 [2]南京医科大学基础医学院,南京211166

出　　处：《临床与实验病理学杂志》2022年第2期142-146,共5页Chinese Journal of Clinical and Experimental Pathology

基　　金：国家自然科学基金(81874258);江苏省卫健委2019年医学科研面上项目(H201966)。

摘　　要：目的探讨胃肠道间质瘤(gastrointestinal stromal tumor,GIST)组织中G蛋白亚单位γ13(G protein subunit gamma 13,GNG13)的表达及与临床病理特征、预后的关系。方法收集122例GIST患者的临床资料,采用免疫组化EnVision法检测GIST组织和癌旁正常组织中GNG13的表达,并复习相关文献。结果GIST组织中GNG13的高表达率(73.8%,90/122)明显高于癌旁正常组织(11.5%,14/122)(P<0.05)。GNG13高表达组肿瘤直径和有丝分裂指数均明显高于GNG13低表达组(P<0.05)。Kaplan-Meier生存曲线显示,GNG13高、低表达组与肿瘤直径、有丝分裂指数的5年生存率相关(P<0.05)。单因素和多因素Cox回归分析显示,GNG13高表达、肿瘤直径和有丝分裂指数增加均是5年生存率降低的独立危险因素(P<0.05)。结论GNG13高表达可能参与GIST的发生、发展,与肿瘤直径和有丝分裂指数增加有关,是影响预后的独立危险因素;GNG13表达不能作为GIST早期诊断的生物学标志物,但对预后判断具有参考意义。Purpose To analyze the expression of G protein subunit 13(GNG13)in gastrointestinal stromal tumor(GIST)and its relationship with pathological features and prognosis,and to provide a new biomarker for prognosis.Methods 122 GIST patients were collected.The immunohistochemical EnVision method was used to detect the expression of GNG13 in tumor tissues and normal tissues adjacent to the tumor.The revelant literatures were reviewed.Results The high expression rate of GNG13 in GIST tissues(73.8%,90/122),which was significantly greater than normal tissue adjacent to the tumor(11.5%,14/122)(P<0.05).The tumor diameter and mitosis in the high GNG13 expression group was higher than those in the low GNG13 expression group(P<0.05).Kaplan-Meier survival curve showed that the expression of GNG13 was correlated with tumor diameter and 5-year survival rate of mitotic index(P<0.05).Univariate and multivariate Cox regression analysis showed that the high expression of GNG13,the increase of tumor diameter and mitotic index was an independent risk factor for 5-year overall survival reduction(P<0.05).Conclusion The high expression of GNG13 may be involved in the occurrence and development of GIST,which is related to the increase of tumor diameter and mitotic index.GNG13 is an independent risk factor for prognosis of GIST patients,GNG13 expression can not be used as a biomarker for early diagnosis of GIST,but it has a certain reference significance for prognosis.

关 键 词：胃肠道间质瘤 G蛋白亚单位γ13 有丝分裂指数 免疫组织化学 

分 类 号：R735.2[医药卫生—肿瘤]