侵袭性NK细胞白血病的实验室特征及诊疗进展  

Research progress on the laboratory characteristics,diagnosis and treatment of invasive NK cell leukemia

作　　者：刘梅[1] 张瑞[1] 毛亚菲 高占玺[1] 史敏[1] LIU Mei;ZHANG Rui;MAO Yafei(Department of Clinical Laboratory,The Second Hospital of Hebei Medical University,Hebei,Shijiazhuang 050000,China)

机构地区：[1]河北医科大学第二医院检验科,050000 [2]河北医科大学第一医院

出　　处：《河北医药》2022年第6期933-937,共5页Hebei Medical Journal

基　　金：河北省自然科学基金项目(编号:H2020206396)。

摘　　要：侵袭性NK细胞白血病(ANKL)是一种少见的NK细胞增殖性疾病。发病急,病情重,进展快,且预后差,当合并噬血细胞综合征(HPS)时,短时间内可出现弥漫性血管内凝血(DIC),导致多脏器衰竭,危及生命。近年来,ANKL的病因及发病机制研究得到进一步阐明,其临床及实验室特征在诊断、疗效监测中愈来愈引起重视。因此,本综述总结了近年来ANKL的病因及发病机制,强调了该疾病的诊断标准及相关治疗的进展。Aggressive NK cell leukemia(ANKL)is a rare disease with proliferative NK cells,which is characterized by acute onset,severe disease condition,fast progress and poor prognosis.If ANKL is combined with hemophagocytic syndrome(HPS),disseminated intravascular coagulation(DIC)may occur in a short time,resulting in multiple organ failure and endangering the life of patients.In recent years,the etiology and pathogenesis of ANKL have been further clarified,and its clinical and laboratory characteristics have attracted increasing attention in diagnosis and efficacy monitoring.This article reviews the progress in the etiology and pathogenesis of ANKL in recent years,emphasizing the diagnostic criteria for the disease and research progress about related treatments.

关 键 词：侵袭性NK细胞白血病 NK细胞 噬血细胞综合征 弥漫性血管内凝血 

分 类 号：R733.7[医药卫生—肿瘤]