Fuchs角膜内皮营养不良患者白内障手术的效果观察  

Observation on the efficacy of cataract surgery in Fuchs endothelial corneal dystrophy patients

作　　者：朱俊英[1] 王骞[1] 肖燕[1] 陈鹏[1] Zhu Junying;Wang Qian;Xiao Yan;Chen Peng(Department of Ophthalmology,The Municipal Second People’s Hospital of Zhengzhou,Zhengzhou 450006,China)

机构地区：[1]郑州市第二人民医院眼科,郑州450006

出　　处：《中华眼外伤职业眼病杂志》2022年第3期193-197,共5页Chinese Journal of Ocular Trauma and Occupational Eye Disease

摘　　要：目的观察Fuchs角膜内皮营养不良(FECD)患者行白内障手术的效果。方法前瞻性研究。纳入郑州市第二人民医院2018年1月至2020年6月FECD患者25例(32眼),所有患者均行白内障摘出联合人工晶状体植入术。随访观察1年。对比手术前后视力、眼压、角膜内皮细胞密度、中央角膜厚度及并发症情况。结果患者术后视力较术前明显提高(F=122.14,P<0.001);手术前后眼压比较差异无统计学意义(F=1.37,P=0.255);术前角膜内皮细胞密度为(2183.87±401.79)个/mm^(2),术后3个月和12个月角膜内皮细胞密度分别为(1896.84±377.56)个/mm^(2)及(1740.23±396.12)个/mm^(2),均较术前明显减少(t=7.22,15.16;P=0.002,0.001);术后各时间点角膜中央厚度与术前对比,差异无统计学意义(F=1.96,P=0.124)。随访期内无角膜并发症出现。结论FECD患者行白内障手术是安全的,但术前需详细评估角膜内皮状况。Objective To observe the efficacy of cataract surgery in Fuchs endothelial corneal dystrophy(FECD)patients.Methods A prospective clinical study.Total of 32 eyes of 25 cataract patients with FECD from Jan.2018 to Jun.2020 in the Municipal Second People’s Hospital of Zhengzhou were included.All patients underwent cataract extraction combined with IOL implantation.The patients were followed up for 1 year.Visual acuity,intraocular pressure(IOP),corneal endothelial cell density(ECD),central corneal thickness and complications were observed before and after operation.Results The visual acuity after operation were improved significantly than that before operation(F=122.14,P<0.001).The differrence of IOP were not statistically significant between before and every time point after operation(F=1.37,P=0.255).The preoperative ECD were(2183.87±401.79)cell/mm^(2),the ECD at 3 and 12 months after operation respectively were(1896.84±377.56)cell/mm^(2) and(1740.23±396.12)cell/mm^(2),which were less significantly than that before surgery(t=7.22,15.16;P=0.002,0.001).The difference of central corneal thickness were not statistically significant between before and each time point after surgery(F=1.96,P=0.255).There was no corneal complication occurred during the follow up time.Conclusion Cataract surgery for FECD patient is safe,but it’s important to evaluate the corneal endothelial cell before the surgery.

关 键 词：营养不良 内皮 角膜 Fuchs 手术 白内障 内皮细胞 角膜 

分 类 号：R779.66[医药卫生—眼科]