老年周围型非小细胞肺癌患者的影像学表现及预后分析  

Imaging manifestations and prognostic analysis of elderly patients with peripheral non-small cell lung cancer

作　　者：刘恒 周九鹏 贾丽娟 LIU Heng;ZHOU Jiupeng;JIA Lijuan(Department of Neurotuberculosis,Xi’an Chest Hospital,Xi’an 710061,Shaanxi,China;Department of Respiratory and Critical Care Medicine,Xi’an Chest Hospital,Xi’an 710061,Shaanxi,China)

机构地区：[1]西安市胸科医院神经结核科,西安710061 [2]西安市胸科医院呼吸与危重症医学科,西安710061

出　　处：《癌症进展》2022年第2期162-165,共4页Oncology Progress

摘　　要：目的探讨老年周围型非小细胞肺癌患者的影像学表现及预后。方法收集101例老年周围型非小细胞肺癌患者的病历资料,比较不同病理类型患者的CT影像学表现,统计患者的2年生存率,采用Cox比例风险模型分析老年周围型非小细胞肺癌患者预后的独立危险因素。结果101例老年周围型非小细胞肺癌患者中,腺癌47例,鳞状细胞癌40例,大细胞癌14例。腺癌患者空泡征、磨玻璃征、胸膜凹陷征及空气支气管征的发生率均高于鳞状细胞癌和大细胞癌患者,腺癌患者毛刺征、支气管血管集束征的发生率均高于大细胞癌患者,差异均有统计学意义(P﹤0.05);而腺癌和鳞状细胞癌患者钙化征、分叶征、毛刺征、空洞形成、支气管血管集束征的发生率比较,差异均无统计学意义(P﹥0.05)。随访2年,59例患者生存,2年生存率为58.42%。单因素分析结果显示,肿瘤直径、空泡征、毛刺征、磨玻璃征、胸膜凹陷征及空气支气管征均可能是老年周围型非小细胞肺癌患者预后的影响因素(P﹤0.01)。多因素分析结果显示,肿瘤直径﹥30 mm、空泡征、毛刺征、磨玻璃征、空气支气管征均是老年周围型非小细胞肺癌患者预后的独立危险因素(P﹤0.05)。结论肿瘤直径﹥30 mm、空泡征、毛刺征、磨玻璃征、空气支气管征均与老年周围型非小细胞肺癌患者的预后有关,掌握老年周围型非小细胞肺癌患者的影像学表现有助于评估患者预后。Objective To investigate the imaging manifestations and prognosis of elderly patients with peripheral non-small cell lung cancer.Method The clinical data of 101 elderly patients with peripheral non-small cell lung cancer was collected.The CT imaging manifestations of patients with different pathological types were compared.The 2-year survival rate was calculated,and the risk factors that affect the prognosis of elderly patients with peripheral non-small cell lung cancer were analyzed by Cox proportional hazard model.Result Among 101 elderly patients with peripheral nonsmall cell lung cancer,47 cases were adenocarcinoma,40 cases were squamous cell carcinoma,and 14 cases were large cell carcinoma.The incidence of vacuole sign,ground glass sign,pleural indentation sign and air bronchogram sign in patients with adenocarcinoma were significantly higher than that in patients with squamous cell carcinoma and large cell carcinoma,the incidence of spicule sign and bronchovascular convergence sign in patients with adenocarcinoma were significantly higher than that in patients with large cell carcinoma,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of calcification sign,lobulation sign,spicule sign,cavitation,bronchovascular convergence sign between patients with adenocarcinoma and squamous cell carcinoma(P>0.05).After 2-year followup,59 patients survived,the survival rate was 58.42%.Univariate analysis showed that tumor diameter,vacuole sign,spicule sign,ground glass sign,pleural indentation sign,and air bronchogram sign may be influence factors that affect the prognosis of elderly patients with peripheral non-small cell lung cancer(P<0.01).Multivariate analysis showed that tumor diameter>30 mm,vacuole sign,spicule sign,ground glass sign,and air bronchogram sign were independent risk factors that affect the prognosis of elderly patients with peripheral non-small cell lung cancer(P<0.05).Conclusion The tumor diameter>30 mm,vacuole sign,spicule sign,ground glass si

关 键 词：周围型非小细胞肺癌 影像学表现 预后 

分 类 号：R734.2[医药卫生—肿瘤]