2012—2016年湖北省肿瘤登记地区结直肠癌发病、死亡状况及趋势分析  

Analysis of the Incidence,Mortality and Trend of Colorectal Cancer in Hubei Cancer Registration Areas from2012 to 2016

作　　者：姚霜 庹吉妤[1] 秦宇 孟繁地 夏雅芬[1] 张敏[1] 魏少忠[2] YAO Shuang;TUO Ji-yu;QIN Yu;MENG Fan-di;XIA Ya-fen;ZHANG Min;WEI Shao-zhong(Hubei Cancer Registration Center,Hubei Cancer Hospital,Wuhan 430079,China;Hubei Cancer Hospital,Wuhan 430079,China)

机构地区：[1]湖北省肿瘤医院湖北省肿瘤登记中心,湖北武汉430079 [2]湖北省肿瘤医院,湖北武汉430079

出　　处：《中国肿瘤》2022年第2期119-126,共8页China Cancer

摘　　要：[目的]分析2012—2016年湖北省肿瘤登记地区结直肠癌的发病、死亡以及疾病负担情况。[方法]收集湖北省肿瘤登记地区2012—2016年结直肠癌发病、死亡资料,采用描述性流行病学方法,通过计算发病/死亡率、年龄别发病/死亡率、中国人口标化率(中标率)、世界人口标化率(世标率)等指标对结直肠癌的发病和死亡情况进行综合分析,同时根据世界卫生组织提供的公式计算伤残调整寿命年(disability-adjusted life years,DALY)和DALY率来估计结直肠癌的疾病负担;并利用Joinpoint回归模型计算年度变化百分比(annual percentage change,APC)及其95%置信区间(confidence interval,CI),分析结直肠癌发病率、死亡率的变化趋势。[结果]2012—2016年湖北省肿瘤登记地区结直肠癌新发病例15912例,发病率为26.02/10万,中标发病率为16.80/10万,世标发病率为16.65/10万。80~84岁年龄组达到发病高峰,为149.84/10万。2012—2016年湖北省肿瘤登记地区结直肠癌死亡病例共计7792例,粗死亡率为12.74/10万,中标死亡率为7.97/10万,世标死亡率为7.86/10万。死亡高峰出现在85+岁年龄组。2012—2016年结直肠癌发病率和死亡率总体趋势较稳定,APC分别为1.03%、2.00%。结直肠癌导致的DALY为129193.73人年,DALY率为2.11/千人。其中结直肠癌DALY率在45岁之前较低,之后逐渐上升,在70~79岁年龄组达到峰值,而80岁之后略微下降。总体来看,男性结直肠癌的DALY率高于女性。[结论]湖北省2012—2016年结直肠癌总体发病率和死亡率男性均高于女性,结直肠癌的DALY率在70~79岁年龄组达到峰值,提示结直肠癌主要集中在老年人群。随着人口老龄化的加速,疾病负担将会越来越严重,湖北省应进一步加强癌症防控工作,男性以及高龄人群应作为结直肠癌防控的重点对象。[Purpose]To analyze the incidence,mortality and disease burden of colorectal cancer in the cancer registration areas of Hubei Province from 2012 to 2016.[Methods]The data of the new cases and deaths of colorectal cancer from 2012 to 2016 in the cancer registration areas of Hubei Province were collected.The crude incidence/mortality rate,age-specific incidence/mortality rate,age-standardized rate by Chinese standard population in 2000(ASRC),age-standardized rates by world standard(Segi’s)population(ASRW)were calculated.The disability-adjusted life years(DALY)and DALY rate were calculated to estimate the disease burden of colorectal cancer;and the Joinpoint regression model was used to calculate the annual percentage change(APC)to analyze the trend of the incidence and mortality of colorectal cancer.[Results]From 2012 to 2016,there were 15912 new cases of colorectal cancer in the cancer registration areas of Hubei Province,with an incidence rate of 26.02/105.The age-standardized incidence rates by 2000’s Chinese standard population was 16.80/105,and the age-standardized incidence rates by world Segi’s population was 16.65/105.In the 80~84 age group,the incidence peaked at 149.84/105.From 2012 to 2016,there were 7792 deaths from colorectal cancer in the cancer registration areas of Hubei Province,with a mortality rate of 12.74/105.The ASRC was 7.97/105,and the ASRW was 7.86/105.The peak of mortality occurred in the 85+age group.The overall incidence and mortality of colorectal cancer were relatively stable,with APC of 1.03%and 2.00%,respectively.The DALY caused by colorectal cancer in 2012—2016 was 129193.73 person-years,and the DALY rate was 2.11/1000 persons.The DALY rate of colorectal cancer was low before the age of 45,and then gradually increased,reaching a peak in the 70~79 age group,and slightly decreased after the age of 80.Overall,the DALY rate of colorectal cancer in men was higher than that in women.[Conclusion]The overall incidence and mortality of colorectal cancer in Hubei Province from 2012 to

关 键 词：结直肠癌 发病率 死亡率 疾病负担 湖北 

分 类 号：R735.3[医药卫生—肿瘤]