Polymorphisms of the Vitamin D Receptor Gene and SexDifferential Associations with Lipid Profiles in Chinese Han Adults  

作　　者：CHEN Yan Mei XU Ping WANG Zhou Tian ZHU Yu Mei GONG Chun Mei HUANG Chang Hua LIU Xiao Li ZHOU Ji Chang 

机构地区：[1]School of Public Health(Shenzhen),Sun Yat-sen University,Shenzhen 518100,Guangdong,China [2]Shenzhen Center for Chronic Disease Control,Shenzhen 518020,Guangdong,China [3]Shenzhen Qilinshan Sanatorium,Shenzhen 518055,Guangdong,China [4]Guangdong Province Engineering Laboratory for Nutrition Translation,Guangzhou 510080,Guangdong,China

出　　处：《Biomedical and Environmental Sciences》2022年第2期115-125,共11页生物医学与环境科学（英文版）

基　　金：supported by the National Natural Science Foundation of China[grant number 81973038];Science,Technology and Innovation Commission of Shenzhen Municipality,China[grant number JCYJ20200109142446804].

摘　　要：Objective To explore the association of single nucleotide polymorphisms(SNPs)of the vitamin D receptor gene(VDR)with circulating lipids considering gender differences.Methods Of the Han Chinese adults recruited from a health examination center for inclusion in the study,the circulating lipids,25-hydroxyvitamin D(25OHD),and other parameters were measured.The VDR SNPs of Cdx2(rs11568820),Fok1(rs2228570),Apa1(rs7975232),and Taq1(rs731236)were genotyped with a qPCR test using blood DNA samples,and their associations with lipids were analyzed using logistic regression.Results In the female participants(n=236 with dyslipidemia and 888 without dyslipidemia),multiple genotype models of Fok1 indicated a positive correlation of B(not A)alleles with LDLC level(P<0.05).In the male participants(n=299 with dyslipidemia and 564 without dyslipidemia),the recessive model of Cdx2 and the additive and recessive models of Fok1 differed(P<0.05)between the HDLC-classified subgroups,respectively,and Fok1 BB and Cdx2 TT presented interactions with 25OHD in the negative associations with HDLC(P<0.05).Conclusion In the Chinese Han adults included in the study,the Fok1 B-allele of VDR was associated with higher LDLC in females,and the Fok1 B-allele and the Cdx2 T-allele of VDR were associated with lower HDLC in males.The interaction of VD and Fok1 BB or Cdx2 TT in males synergistically decreased HDLC levels.

关 键 词：Vitamin D Vitamin D receptor Gene polymorphism LIPID DYSLIPIDEMIA 

分 类 号：R589.2[医药卫生—内分泌]