地奥司明联合激素术前干预对直肠癌新辅助放化疗后手术及并发症的影响  

Influence of (Diosmin+Hormone) Preoperative Intervention on the Surgery Following Neoadjuvant Radiochemotherapy for Rectal Cancer,as well as on the Complication after the Surgery

作　　者：赵春波 孙军席[1] 冷晓刚[1] 郑升 刘铁[1] ZHAO Chun-bo;SUN Jun-xi;LENG Xiao-gang;ZHENG Sheng;LIU Tie(Coloproctological Surgery Dept,Weifang City's People's Hospital,Shandong 261000)

机构地区：[1]山东省潍坊市人民医院肛肠外科,山东潍坊261000

出　　处：《中国肛肠病杂志》2021年第12期12-14,共3页Chinese Journal of Coloproctology

摘　　要：为评估地奥司明联合激素术前干预对直肠癌新辅助放化疗后手术及术后并发症的影响,选择103例局部进展期直肠癌新辅助放化疗患者,根据术前是否联合用药分为观察组32例和对照组71例,观察组术前给予地奥司明联合激素干预,对照组术前不使用上述药物干预。观察比较2组手术时间、术后并发症及恢复情况。结果显示,2组干预前肿瘤特征及基本信息比较,差异无统计学意义(P>0.05)。观察组手术时间短于对照组(P <0.05),吻合口漏发生率(3.12%)显著低于对照组(12.67%),差异均有统计学意义(P <0.05)。术后第一次排气时间、排便时间,进食时间、引流管拔除时间及住院时间比较,差异无统计学意义(P>0.05)。结果表明,局部进展期直肠癌联合新辅助放化疗后至手术期间应用地奥司明及激素治疗,可明显缩短手术时间,减少术后吻合口漏发生率,且对患者术后恢复无明显影响。This study was to investigate the influence of(diosmin+hormone)preoperative intervention on the surgery after neoadjuvant radio-chemotherapy for rectal cancer,as well as on the complication following the surgery,enrolled 103 patients with locally advanced rectal cancer and underwent noadjuvant radiochemotherapy into this study:according to with or without preoperatively using drugs divided them into observation group[32 cases,before surgery received(diosmin+hormone)intervention]and control group(71 cases did not receive above drugs intervention);then,observed and compared both groups’ operating time,postoperative complication,and patients recovered status.As results,in the tumor feature and patients’ basic information before intervention there was no statistical difference between the two groups(P >0.05);in operating time,and in the incidence of anastomotic leakage observation group was respectively shorter,lower(3.12% vs 12.67%)than control group(all,P <0.05);in the time for first flatus from anus,for defecation,for eating,for drainage tube extubated,and for hospitalization,there was all no statistical difference between the two groups(P <0.05).Results show that from the end of neoadjuvant radiochemotherapy to implementing surgery administering(diosmin+hormone)can significantly shorten operating time,reduce the incidence of anastomotic leakage,but does not influence patients’ postoperative rehabilitation significantly.

关 键 词：直肠癌 新辅助放化疗 地奥司明 激素 疗效 

分 类 号：R735.37[医药卫生—肿瘤]