泮托拉唑联合氨甲苯酸治疗急性上消化道出血的效果观察  

Clinical effect of pantoprazole combined with aminomethylbenzoic acid on acute upper gastrointestinal hemorrhage

作　　者：刘鑫[1] 许春进[2] Liu Xin;Xu Chunjin(Department of Emergency,Shangqiu First People’s Hospital,Shangqiu 476100,China;Department of Gastroenterology,Shangqiu First People’s Hospital,Shangqiu 476100,China)

机构地区：[1]河南省商丘市第一人民医院急诊科,476100 [2]河南省商丘市第一人民医院消化内科,476100

出　　处：《中国实用医刊》2022年第1期113-116,共4页Chinese Journal of Practical Medicine

摘　　要：目的分析泮托拉唑联合氨甲苯酸治疗急性上消化道出血(AUGIH)的临床效果。方法抽取2019年1月至2020年12月商丘市第一人民医院收治的60例AUGIH患者为研究对象,以随机数字表法分为观察组和对照组,每组30例。两组均接受常规治疗,在此基础上,对照组采用泮托拉唑治疗,观察组采用泮托拉唑联合氨甲苯酸治疗,均治疗3 d。比较两组的临床指标(止血时间、输血量、住院时间及再出血率);比较两组治疗前及治疗后3 d的炎症指标[超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)水平]及Blatchford评分;比较两组治疗期间的不良反应发生率。结果与对照组比较,观察组止血、住院时间较短,输血量较少(P<0.05);两组再出血率比较差异未见统计学意义(P>0.05)。治疗后3 d,两组血清hs-CRP、TNF-α、IL-6水平及Blatchford评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异未见统计学意义(P>0.05)。结论泮托拉唑联合氨甲苯酸治疗AUGIH可提高止血效率,减少输血量,降低炎症反应,改善患者病情程度,缩短住院时间。Objective To analyze the clinical effect of pantoprazole combined with aminomethylbenzoic acid in the treatment of acute upper gastrointestinal hemorrhage(AUGIH).Methods Sixty patients with AUGIH treated in Shangqiu First People’s Hospital from January 2019 to December 2020 were selected as the research subjects,and they were divided into control group and observation group by random number table method,with 30 cases in each group.Both groups received conventional treatment,on this basis,the control group was treated with pantoprazole,and the observation group was treated with pantoprazole combined with aminomethylbenzoic acid,and both groups were treated for 3 days.The clinical indexes(hemostasis time,amount of blood transfusion,hospital stay and rebleeding rate)were compared between the two groups;the inflammatory indexes,including high sensitivity C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6),and Blatchford score were compared between the two groups before and 3 days after treatment.The incidence of adverse reactions of the two groups during treatment were compared.Results Compared with control group,the observation group had shorter hemostasis time and hospital stay,and less blood transfusion volume(P<0.05).There was no significant difference in rebleeding rate between the two groups(P>0.05).After 3 days of treatment,levels of serum hs-CRP,TNF-α,IL-6,and Blatchford score in the two groups were lower than those before treatment,and those indexes in the observation group were lower than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions Pantoprazole combined with aminomethylbenzoic acid in the treatment of AUGIH can improve the hemostasis efficiency,reduce the amount of blood transfusion,reduce the inflammatory reaction,improve the disease condition of patients,and shorten the hospital stay.

关 键 词：上消化道出血 泮托拉唑 氨甲苯酸 炎症指标 Blatchford评分 

分 类 号：R573.2[医药卫生—消化系统]