血必净注射液辅助治疗原发性肝癌介入术后综合征的临床研究  

Efficacy of Xuebijing injection in the treatment of post-interventional Syndrome of primary liver cancer and its effects on liver function and serum CRP,TNF-AND VEGF levels

作　　者：李辉 李海霞[2] 王秀香[1] Li Hui;Li Haixia;Wang Xiuxiang(CT Department,Cangzhou Infectious Disease Hospital,Hebei Cangzhou 061014,China;Radiology Department,Cangzhou Infectious Disease Hospital,Hebei Cangzhou 061014,China)

机构地区：[1]沧州市传染病医院CT科,河北沧州061014 [2]沧州市传染病医院放射科,河北沧州061014

出　　处：《中华介入放射学电子杂志》2022年第1期27-31,共5页Chinese Journal of Interventional Radiology：electronic edition

摘　　要：目的探讨血必净注射液治疗原发性肝癌(PHC)介入术后综合征的疗效及对肝功能和血清C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)和血管内皮生长因子(VEGF)水平的影响。方法将我院收治的102例PHC介入术后综合征患者随机分成两组,每组51例。两组均给予常规治疗,观察组联合血必净注射液治疗,比较两组的疗效和安全性。比较两组治疗前后中医证候总积分、肝功能指标[谷草转氨酶(AST)、谷丙转氨酶(ALT)、总胆红素(TBIL)]、血清CRP、TNF-α和VEGF水平的变化情况。结果观察组总有效率为80.39%,与对照组的56.86%相比显著上升(P<0.05)。两组术后3、7 d中医证候总积分均显著下降(P<0.05);且以观察组降低更显著(P<0.05)。观察组肝区疼痛、发热、恶心呕吐、腹泻的持续时间均显著短于对照组(P<0.05)。两组术后3 d时血清ALT、AST、TBIL、CRP、TNF-α水平均较本组术前显著升高(P<0.05),术后7 d时则均较本组术后3 d时显著降低(P<0.05);且观察组术后3、7 d时血清ALT、AST、TBIL、CRP、TNF-α水平均显著低于对照组同时点(P<0.05)。两组术后血清VEGF水平均显著升高(P<0.05),但术后7 d相比观察组显著更低(P<0.05)。所有受试者均无明显不良反应发生。结论血必净注射液辅助治疗PHC介入术后综合征能有效抑制血清炎性因子与VEGF表达,减轻肝损伤,疗效确切。Objective To investigate the efficacy of Xuebijing injection on hepatic function and serum c-reactive protein(CRP),tumor necrosis Factor-alpha(TNF-α)and Vascular endothelial growth factor in patients with primary hepatic Carcinoma(PHC)after interventional therapy.Methods A total of 102 patients with PHC Post-intervention Syndrome were randomly divided into two groups,51 cases in each group.Two groups were given conventional treatment,observation group combined with Xuebijing injection treatment.The efficacy and safety of the two groups were compared.The changes of TCM syndrome total score,liver function index[aspartate transaminase,alanine transaminase,total Bilirubin(TBIL)],the levels of serum CRP,TNF-αand VEGF were compared between the two groups before and after treatment.Results The total effective rate of the observation group was 80.39%,which was significantly higher than that of the control group(56.86%)(P<0.05).The total score of TCM Syndrome in both groups decreased significantly(P<0.05)on the 3 rd and 7 th days after operation,and the decrease was more significant in the observation group(P<0.05).The duration of pain,fever,nausea,vomiting and diarrhea in the observation group was significantly shorter than that in the control group(P<0.05).The levels of serum ALT,AST,TBIL,CRP and TNF-αin the two groups were significantly increased 3 d after the operation compared with those before operation(P<0.05),and significantly decreased 7 d after the operation compared with those 3 d after the operation(P<0.05)The serum levels of ALT,AST,TBIL,CRP and TNF-αin the observation group were significantly lower than those in the control group at the same time point(P<0.05).The levels of serum VEGF in the two groups were increased significantly after the operation(P<0.05).However,the serum VEGF level in observation group was significantly lower than that in control group 7 days after operation(P<0.05).There was no obvious adverse reaction in all subjects.Conclusions Xuebijing injection can effectively inhibit the expr

关 键 词：血必净注射液 原发性肝癌介入术后综合征 肝功能 炎症反应 血管内皮生长因子 

分 类 号：R735.7[医药卫生—肿瘤]