BAFF及IL-6在儿童自身免疫性脑炎中的表达及意义  

Expression and Significance of BAFF and IL-6 in Children with Autoimmune Encephalitis

作　　者：谭自明 罗琼[1] 张美[1] 王君[1] TAN Zi-ming;LUO Qiong;ZHANG Mei;WANG Jun(Department of Pediatric Neurology,the First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054,Xinjiang,China)

机构地区：[1]新疆医科大学第一附属医院儿童神经内科,新疆乌鲁木齐830054

出　　处：《医学信息》2022年第5期134-136,共3页Journal of Medical Information

摘　　要：目的探究B细胞活化因子(BAFF)及白细胞介素-6(IL-6)在儿童自身免疫性脑炎中的表达水平及意义。方法回顾性分析2018年3月-2021年3月在我院接受脑炎检查的155例儿童的临床资料,按照最后诊断结果将其分为观察组A(52例自身免疫性脑炎儿童)、观察组B(53例病毒性脑炎患儿)和对照组(50例非脑炎儿童)。比较三组血液及脑脊液中BAFF及IL-6的表达水平。结果观察组A和观察组B血液、脑脊液中BAFF及IL-6水平均高于对照组,差异有统计学意义(P<0.05);观察组A血液、脑脊液中BAFF及IL-6水平均高于观察组B,差异有统计学意义(P<0.05)。结论BAFF及IL-6在儿童自身免疫性脑炎中具有较高的表达水平,在帮助诊断及鉴别儿童自身免疫性脑炎中具有一定的应用价值,可为该病的治疗提供参考。Objective To explore the expression levels and significance of B cell activating factor(BAFF)and interleukin-6(IL-6)in children with autoimmune encephalitis.Methods The clinical data of 155 children who underwent encephalitis examination in our hospital from March 2018 to March 2021 were retrospectively analyzed.According to the final diagnosis,they were divided into observation group A(52 children with autoimmune encephalitis),observation group B(53 children with viral encephalitis)and control group(50 children without encephalitis).The expression levels of BAFF and IL-6 in blood and cerebrospinal fluid of the three groups were compared.Results The levels of BAFF and IL-6 in blood and cerebrospinal fluid of observation group A and observation group B were higher than those of control group,and the difference was statistically significant(P<0.05).The levels of BAFF and IL-6 in blood and cerebrospinal fluid of observation group A were higher than those of observation group B,and the difference was statistically significant(P<0.05).Conclusion BAFF and IL-6 have high expression levels in children with autoimmune encephalitis,and have certain application value in helping the diagnosis and identification of children with autoimmune encephalitis,which can provide reference for the treatment of the disease.

关 键 词：B细胞活化因子 白细胞介素-6 自身免疫性脑炎 病毒性脑炎 

分 类 号：R742.9[医药卫生—神经病学与精神病学]