晚期不可切除肝癌的综合治疗  

Comprehensive therapy for advanced unresectable hepatocellular carcinoma

作　　者：邢家利 金保 徐岗 王禹歆 万雪帅[1] 郑永昌[1] 徐海峰 徐意瑶[1] 管梅[2] 杜顺达 赵海涛[1] 卢欣 桑新亭[1] 毛一雷 Xing Jiali;Jin Bao;Xu Gang;Wang Yuxin;Wan Xueshuai;Zheng Yongchang;Xu Haifeng;Xu Yiyao;Guan Mei;Du Shunda;Zhao Haitao;Lu Xin;Sang Xinting;Mao Yilei(Department of Liver Surgery,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences,Beijing 100730,China;Department of Medical Oncology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences,Beijing 100730,China)

机构地区：[1]中国医学科学院北京协和医院肝脏外科,北京100730 [2]中国医学科学院北京协和医院肿瘤内科,北京100730

出　　处：《中华普通外科杂志》2022年第2期108-112,共5页Chinese Journal of General Surgery

基　　金：国家自然科学基金(81972698);湖北陈孝平科技发展基金会肝胆胰恶性肿瘤研究基金(CXPJJH11900001-2019215)。

摘　　要：目的探讨综合治疗对晚期不可切除肝癌治疗的疗效及安全性。方法回顾性分析2018年11月到2020年12月, 在北京协和医院就诊的, 初治不能根治性手术切除的, 而应用综合治疗的34例原发性肝癌患者的临床资料。结果 34例患者均按计划完成了综合治疗, 无严重不良事件发生。其中6例患者治疗效果评估为部分缓解, 成功接受了手术;7例患者治疗效果为疾病稳定, 无明显进展;21例患者治疗效果为疾病进展。结论对不同患者应用综合治疗能够使一部分患者实现转化手术获得根治性切除。Objective To investigate the efficacy and safety of comprehensive therapy in the treatment of advanced unresectable hepatocellular carcinoma.Methods Clinical data of 34 patients with primary liver cancer admitted to Peking Union Medical College Hospital from Nov 2018 to Dec 2020 initially evaluated as unresectable were treated firstly by combined therapy and then underwent reevaluation for further management.Results A total of 34 patients completed the integrative treatment,and no serious adverse events occurred.Among them,6 patients were evaluated as partial remission,and underwent successful tumor resection,tumors in 7 patients were stable,and 21 patients suffered from disease progression.Conclusion After comprehensive therapy,unresectable tumors in some patients could reduce and be rendered resection.

关 键 词：肝肿瘤 综合治疗 安全性 疗效 

分 类 号：R735.7[医药卫生—肿瘤]