乳腺癌超声造影参数与Ki-67、HER-2及雌孕激素水平的相关性  

Correlations between Contrast-enhanced Ultrasound Parameters with Levels of Ki-67,HER-2 and Estrogen Progesterone in Patients with Breast Cancer

作　　者：马维东 张丹丹 苏洁 王书伟[1] 朱丽[1] 黄梅[1] 张超[2] MA Wei-dong;ZHANG Dan-dan;SU Jie;WANG Shu-wei;ZHU Li;HUANG Mei;ZHANG Chao(The First Department of Ultrasound,Cangzhou Hospital of Integrated Traditional Chinese and Western medicine,Cangzhou,Hebei 061001,China;Department of Breast Surgery,Cangzhou Hospital of Integrated Traditional Chinese and Western medicine,Cangzhou,Hebei 061001,China;the Second Department of Orthopedics,People's Hospital of Renqiu City,Cangzhou,Hebei 062550,China)

机构地区：[1]河北省沧州中西医结合医院超声一科,河北沧州061001 [2]河北省沧州中西医结合医院乳腺外科,河北沧州061001 [3]任丘市人民医院骨二科,河北任丘062550

出　　处：《临床误诊误治》2022年第3期73-77,共5页Clinical Misdiagnosis & Mistherapy

基　　金：河北省医学科学研究课题计划项目(20211543)。

摘　　要：目的探讨乳腺癌超声造影参数与增殖细胞核抗原(Ki-67)、人表皮生长因子受体-2(HER-2)及雌孕激素水平的相关性。方法选择2019年9月—2021年9月行手术治疗的乳腺癌100例,术前均行超声造影检查获得乳腺癌病灶区域的血流灌注参数(达峰时间、增强幅度、上升支斜率、曲线下面积、梯度);术后癌组织以免疫组织化学法检测Ki-67、HER-2及雌激素受体(ER)、孕激素受体(PR)表达情况。比较Ki-67、HER-2、ER、PR阳性及阴性患者的超声造影参数的差异,并分析其与超声造影参数的相关性。结果乳腺癌Ki-67、HER-2、ER、PR阳性率分别为84.00%、77.00%、67.00%、65.00%。Ki-67阳性患者超声造影增强幅度、上升支斜率、梯度高于Ki-67阴性患者,曲线下面积大于Ki-67阴性患者(P<0.05)。HER-2阳性患者超声造影达峰时间短于HER-2阴性患者,上升支斜率高于HER-2阴性患者(P<0.05)。ER阳性患者超声造影达峰时间短于ER阴性患者,上升支斜率高于ER阴性患者(P<0.05)。PR阳性超声造影达峰时间短于PR阴性患者,上升支斜率高于PR阴性患者(P<0.05)。超声造影达峰时间与HER-2、ER、PR呈负相关,上升支斜率与Ki-67、HER-2、ER、PR呈正相关,增强幅度、曲线下面积及梯度与Ki-67呈正相关(P<0.01)。结论乳腺癌患者免疫组织化学指标Ki-67、HER-2、ER、PR与超声造影参数关系密切。Objective To investigate correlations between contrast-enhanced ultrasound(CEUS)parameters with levels of proliferating cell nuclear antigen(Ki-67),human epidermal growth factor receptor-2(Her-2)and estrogen progesterone in patients with breast cancer.Methods A total of 100 patients with breast cancer who had undergone surgical treatment between September 2019 and September 2021 were included in this study.All patients underwent preoperative CEUS examinations to obtain blood perfusion parameters[time-to-maximum(Tmax),enhancement amplitude and ascending branch slope,the area under the curve,gradient]in breast cancer lesions.Expressions of Ki-67,HER-2,estrogen receptor(ER)and progesterone receptor(PR)in cancerous tissues were detected by immunohistochemistry.Differences of CEUS parameters were compared among patients with positive and negative Ki-67,HER-2,ER and PR,and their correlations with CEUS parameters were analyzed.Results The positive rates of Ki-67,HER-2,ER and PR in patients of breast cancer were 84.00%,77.00%,67.00%and 65.00%respectively.Values of enhancement amplitude,ascending branch slope and gradient of CEUS and the area under the curve in patients with positive KI-67were significantly larger than those in patients with negative Ki-67(P<0.05).In breast cancer patients with positive HER-2,Tmax of CEUS was significantly shorter than that in breast cancer patients with negative HER-2,while the ascending branch slope was significantly higher than that in breast cancer patients with negative HER-2(P<0.05).In breast cancer patients with positive ER,Tmax of CEUS was significantly shorter than that in breast cancer patients with negative ER,while the ascending branch slope was significantly higher than that in breast cancer patients with negative ER(P<0.05).In breast cancer patients with positive PR,Tmax of CEUS was significantly lower than that in breast cancer patients with negative PR,while the ascending branch slope was significantly higher than that in breast cancer patients with negative PR(P<0.05).Tma

关 键 词：乳腺肿瘤 超声造影 增殖细胞核抗原 受体 表皮生长因子 受体 雌激素 孕激素受体 

分 类 号：R737.9[医药卫生—肿瘤]