急性脑梗死患者血清Lp-PLA2水平与其疾病严重程度和复发风险的关系  

Relationship Between Serum Lp-PLA2 Level and Disease Severity and Recurrence Risk in Patients with Acute Cerebral Infarction

作　　者：方骁[1] 邢慧娟[1] 郝文莉[1] FANG Xiao;XING Huijuan;HAO Wenli(The Third People's Hospital of Dalian,Dalian 116000,China)

机构地区：[1]大连市第三人民医院,辽宁大连116000

出　　处：《航空航天医学杂志》2022年第1期21-23,共3页Journal of Aerospace medicine

摘　　要：目的分析急性脑梗死患者脂蛋白相关磷脂酶A2(Lp-PLA2)水平与其疾病严重程度和复发风险的关系。方法选取2018年3月-2020年12月进行体检的健康者60例,设为对照组;选取同期收治的急性脑梗死患者60例,设为研究组,通过颈动脉超声检查结果,根据不同斑块性质将其分为混合斑块组(n=16)、稳定斑块组(n=5)、不稳定斑块组(n=39);根据患者复发情况分为未复发组(n=41)、复发组(n=19)。比较不同性质颈动脉斑块患者的Lp-PLA2水平、复发组与未复发组血清LpPLA2水平、采用Pearson分析Lp-PLA2水平与急性脑梗死复发风险的相关性,单因素logistic回归分析Lp-PLA2水平分别与急性脑梗死严重程度。结果未复发组Lp-PLA2水平明显低于复发组(P<0.05)。对照组Lp-PLA2水平低于不稳定斑块组,不稳定斑块组Lp-PLA2水平低于混合斑块组,混合斑块组Lp-PLA2水平低于稳定斑块组(P<0.05);Lp-PLA2(OR=6.216,95%CI:3.156~13.372,P=0.003)为脑梗死复发可能的独立危险因素;Pearson相关性分析结果显示,Lp-PLA2水平与急性脑梗死严重程度呈正相关(r=0.418,P<0.05)。结论 Lp-PLA2可能是急性梗死复发的独立危险因素,Lp-PLA2水平与急性脑梗死严重程度具有相关性,Lp-PLA2水平越高,病情越严重,复发风险越大。Objective To analyze the relationship between lipoprotein associated phospholipase A2(Lp-PLA2) level and disease severity and recurrence risk in patients with acute cerebral infarction. Methods 60 healthy subjects who underwent physical examination in our hospital from March 2018 to December 2020 were selected as the control group;60 patients with acute cerebral infarction treated in our hospital in the same period were selected as the study group. According to the results of carotid ultrasound, they were divided into mixed plaque group(n=16), stable plaque group(n=5) and unstable plaque group(n=39);According to the recurrence, the patients were divided into non recurrence group(n=41) and recurrence group(n=19).The level of Lp-PLA2 in patients with different types of carotid plaque, the level of serum lppla2 in recurrent group and non recurrent group, the correlation between Lp-PLA2 level and the risk of recurrence of acute cerebral infarction was analyzed by Pearson, and the level of Lp-PLA2 and the severity of acute cerebral infarction were analyzed by univariate logistic regression. Results The level of LP-PLA2 in non-recurrent group was significantly lower than that in recurrent group(P<0.05). The level of LP-PLA2 in control group was lower than that in unstable plaque group, the level of LP-PLA2 in unstable plaque group was lower than that in mixed plaque group, and the level of LP-PLA2 in mixed plaque group was lower than that in stable plaque group(P<0.05). Lp-pla2(OR=6.216,95%CI:3.156-13.372,P=0.003) was an independent risk factor for recurrence of cerebral infarction. Pearson correlation analysis showed that THE level of LP-PLA2 was positively correlated with the severity of acute cerebral infarction(R=0.418,P<0.05). Conclusions Lp-PLA2 may be an independent risk factor for the recurrence of acute infarction. The level of Lp-PLA2 is correlated with the severity of acute cerebral infarction. The higher the level of Lp-PLA2, the more serious the condition is, and the greater the risk of recurrence.

关 键 词：急性脑梗死 脂蛋白相关磷脂酶A2 复发风险 

分 类 号：R743.3[医药卫生—神经病学与精神病学]