事件相关电位P300在精神分裂症中的状态性与素质性  

The Status and Diathesis Attributes of the Event-Related Potential P300 in Schizophrenia

作　　者：邓欣童 刘璠 王丹 王霜 胡丁千 Deng Xintong;Liu Fan;Wang Dan;Wang Shuang;Hu Dingqian(Department of Psychological Examination,Guangyuan Mental Health Center,Guangyuan Sichuan 628000,China)

机构地区：[1]广元市精神卫生中心心理检测科,四川广元628000

出　　处：《医疗装备》2022年第5期109-112,共4页Medical Equipment

基　　金：广元市科学技术与知识产权局重点研发项目(19ZDYF0125)。

摘　　要：目的探究事件相关电位P300在精神分裂症中的状态性和素质性。方法选取2018年8月至2021年2月医院收治的90例精神分裂症患者作为试验组,并将试验组按时间和症状表现分为首发组、缓解组和康复组,另选取同期医院的职工和实习生共30名作为对照组,采用阳性症状量表(SAPS)、阴性症状量表(SANS)对对照组和试验组进行评分,并运用事件相关电位P300检测对照组和试验组波形和潜伏期,分析组间差异。结果经Pearson相关分析显示,SAPS评分与P300波幅成负相关(r=-0.26,P<0.05),SANS评分与P300波幅成负相关(r=-0.43,P<0.01);SAPS、SANS评分与P300潜伏期均未见明显相关性。4组P300波幅比较,差异有统计学意义(F=23.88,P<0.01);对照组与首发组、缓解组、康复组P300波幅比较,差异均有统计学意义(P<0.05);康复组与首发组、缓解组P300波幅比较,差异均有统计学意义(P<0.05);缓解组与首发组P300波幅比较,差异无统计学意义(P>0.05)。4组P300潜伏期比较,差异有统计学意义(F=5.81,P<0.01);对照组与首发组、缓解组、康复组P300潜伏期比较,差异均有统计学意义(P<0.05);首发组、缓解组、康复组P300潜伏期比较,差异无统计学意义(P>0.05)。结论事件相关电位P300的波幅会随着症状和病情的改善而增大,具有状态性属性;潜伏期随着症状和病情的改善未见明显改变,具有素质性属性。事件相关电位P300在精神分裂症中属于混合性指标。Objective The status and diathesis attributes of the event-related potential P300 in schizophrenia were explored and defined.Methods A total of 90 patients with schizophrenia who were hospitalized in the hospital from August 2018 to February 2021 were selected as the test group,and they were divided into 3 groups(the first-episode group,the remission group and the rehabilitation group)according to the episode time and symptoms.30 employees and interns in the hospital during the same period were selected as the control group.The scale for assessment of positive symptoms(SAPS)and the scale for assessment of negative symptoms(SANS)were used to score for the control group and the test group.The eventrelated potential P300 was used to detect the amplitude and latency to explore the differences among the groups.Results The Pearson correlation analysis results showed that the SAPS score was inversely correlated with the P300 amplitude(r=-0.26,P<0.05)and the SANS score was inversely correlated with the P300 amplitude(r=-0.43,P<0.01);There was no significant correlation between the SAPS or SANS scores and P300 latency;When the P300 amplitude of the 4 groups were compared,the difference was statistically significant(F=23.88,P<0.01);When the P300 amplitude of the control group was compared with those of the first-episode group,the remission group and the rehabilitation group respectively,the differences were all statistically significant(P<0.05);When the P300 amplitude of the rehabilitation group was compared with those of the first-episode group and the remission group,and the differences were statistically significant(P<0.05);When the P300 amplitude of the rehabilitation group was compared with that of the first-episode group,the difference was not statistically significant(P>0.05).When the P300 latency of the 4 groups were compared,the difference was statistically significant(F=5.81,P<0.01);When the P300 latency of the control group was compared with those of the first-episode group,the remission group and the rehabilita

关 键 词：精神分裂症 事件相关电位 状态性 素质性 

分 类 号：R749.3[医药卫生—神经病学与精神病学]