Rho激酶信号通路对小梁网细胞增殖作用机制的研究进展  

RESEARCH ADVANCES IN THE MECHANISM OF ACTION OF THE RHO KINASE SIGNALING PATHWAY IN THE PROLIFE-RATION OF TRABECULAR MESHWORK CELLS

作　　者：刘璐[1] 姜文澜 杨雪娇 杨先[1] LIU Lu;JIANG Wenlan;YANG Xuejiao;YANG Xian(Department of Ophthalmology,The Affiliated Hospital of Qingdao University,Qingdao 266003 China)

机构地区：[1]青岛大学附属医院眼科,山东青岛266003

出　　处：《青岛大学学报（医学版）》2022年第1期155-158,共4页Journal of Qingdao University(Medical Sciences)

基　　金：国家自然科学基金青年科学基金项目(81600726);中国博士后科学基金项目(2017M622141);山东省自然科学基金项目(ZR2016HB53);青岛市市南区科技计划项目(2020-2-007-YY);青岛市博士后应用研究项目(2016051)。

摘　　要：新型降眼压药物Rho激酶抑制剂直接作用于青光眼根本的致病部位——小梁网及小梁网细胞,通过调节细胞周期、细胞骨架,促进细胞增殖等多种机制降眼压。本文将针对Rho激酶信号通路对小梁网细胞增殖作用机制的研究进展进行综述。Rho kinase inhibitors,as a novel type of intraocular pressure(IOP)-lowering drugs,act directly on trabecular meshwork and trabecular meshwork cells,which are the underlying pathogenic sites of glaucoma,and they reduce IOP through various mechanisms including regulating cell cycle and cytoskeleton and promoting cell proliferation.This article reviews the research advances in the mechanism of action of this pathway in the proliferation of trabecular meshwork cells.

关 键 词：青光眼 RHO相关激酶类 信号系统 小梁网 细胞增殖 综述 

分 类 号：R775[医药卫生—眼科] R345.57[医药卫生—临床医学]