急性脑梗死患者血清Lp-PLA2、MIF的表达及其与神经功能缺损的相关性  

The expression of serum Lp-PLA2 and MIF in patients with acute cerebral infarction and its correlation with neurological deficits

作　　者：刘丽娜[1] 赵红敏[1] 王静[1] 田惠玉[1] 谢冰川[2] Liu Lina;Zhao Hongmin;Wang Jing;Tian Huiyu;Xie Bingchuan(Department of General Medicine,the First Hospital of Hebei Medical University,Hebei Province,Shijiazhuang 050011,China;不详)

机构地区：[1]河北医科大学第一医院全科医学科,石家庄050011 [2]河北医科大学第一医院神经内科,石家庄050011

出　　处：《疑难病杂志》2022年第3期242-246,共5页Chinese Journal of Difficult and Complicated Cases

基　　金：河北省医学科学研究课题计划(20211722)。

摘　　要：目的分析急性脑梗死(ACI)患者血清脂蛋白磷脂酶A2(Lp-PLA2)、巨噬细胞移动抑制因子(MIF)的表达及其与神经功能缺损(ND)程度的相关性。方法选择2020年6月—2021年6月河北医科大学第一医院全科医学科诊治ACI患者86例。于急性期(发病第2天)、恢复期(发病第15天)测定ACI患者实验室指标,并采用美国国立卫生研究院卒中量表(NIHSS)评估ND程度,比较急性期和恢复期血清Lp-PLA2、MIF表达。在急性期、恢复期,分别根据NIHSS评分分为中重度组(>4分)、轻度组(≤4分),比较2组临床资料,分析血清Lp-PLA2、MIF表达与急性期、恢复期ACI患者ND程度的相关性。绘制决策曲线分析急性期、恢复期血清Lp-PLA2、MIF评估ACI患者ND程度的净受益率。结果与急性期比较,ACI患者恢复期血清Lp-PLA2、MIF,NIHSS评分降低(t/P=12.833/<0.001、9.812/<0.001、24.195/<0.001);急性期中重度组ACI患者血清Lp-PLA2、MIF高于轻度组(t/P=8.457/<0.001、6.666/<0.001);恢复期中重度组ACI患者血清Lp-PLA2、MIF高于轻度组(t/P=7.452/<0.001、7.605/<0.001);血清Lp-PLA2、MIF表达与急性期、恢复期ACI患者ND程度均呈正相关(急性期:r/P=0.390/<0.001、0.498/<0.001;恢复期:r/P=0.390/<0.001、0.428/<0.001);决策曲线结果显示,急性期、恢复期血清Lp-PLA2、MIF评估ACI患者ND程度的净受益率最大值分别为0.674、0.672,且不同时期两者联合的模型评估ACI患者ND程度的净受益率优于单纯Lp-PLA2或MIF。结论ACI患者血清Lp-PLA2、MIF的表达随ACI恢复而降低,与ND程度有关,在急性期、恢复期均可用于ND程度评估。Objective To analyze the expression of serum lipoprotein phospholipase A2(Lp-PLA2)and macrophage migration inhibitory factor(MIF)in patients with acute cerebral infarction(ACI)and their correlation with the degree of neurological impairment(ND).Methods From June 2020 to June 2021,86 cases of ACI patients were diagnosed and treated in the Department of General Medicine of the First Hospital of Hebei Medical University.The laboratory indicators of ACI patients were measured in the acute phase(the 2 nd day of onset)and the recovery phase(the 15 th day of onset),and the National Institutes of Health Stroke Scale(NIHSS)was used to assess the degree of ND.Compare the expression of serum Lp-PLA2 and MIF in the acute phase and the convalescent phase.In the acute phase and the recovery phase,according to the NIHSS score,they were divided into a moderate-severe group>4 points and a mild group≤4 points.The clinical data of the two groups were compared,and the serum Lp-PLA2,MIF expression and the ND degree of ACI patients in the acute and recovery phases were analyzed.Correlation.Draw a decision curve to analyze the net benefit rate of serum Lp-PLA2 and MIF in assessing the degree of ND in ACI patients during the acute and recovery phases.Results Compared with the acute phase,the serum Lp-PLA2,MIF,and NIHSS scores of ACI patients during the recovery phase decreased(t/P=12.833/<0.001,9.812/<0.001,24.195/<0.001).Serum Lp-PLA2 and MIF of ACI patients in the acute phase of the moderate to severe group were higher than those in the mild group(t/P=8.457/<0.001,6.666/<0.001).Serum Lp-PLA2 and MIF of ACI patients in the moderate to severe group during the recovery period were higher than those in the mild group(t/P=7.452/<0.001,7.605/<0.001).Serum Lp-PLA2 and MIF expression are positively correlated with the ND degree of ACI patients in acute and convalescent phases(acute phase:r/P=0.390/<0.001,0.498/<0.001.convalescent phase:r/P=0.390/<0.001,0.428/<0.001).The results of the decision curve show that the maximum net benefit rate of

关 键 词：急性脑梗死 神经功能缺损 脂蛋白磷脂酶A2 巨噬细胞移动抑制因子 相关性 

分 类 号：R743.33[医药卫生—神经病学与精神病学]