血管性痴呆患者血清IGF-1、IGFBP-3表达水平与认知损害的相关性分析  

Correlation Analysis of Cognitive Impairment with Serum IGF-1 and IGFBP-3 Expression in Patients with Vascular Dementia

作　　者：苏航 蒋兴文 SU Hang;JIANG Xing-wen(Department of Neurology,Xi'an XD Group Hospital,Xi'an 710077)

机构地区：[1]西电集团医院神经内科,陕西西安710077 [2]安康市中心医院康复医学科,陕西安康725000

出　　处：《医学临床研究》2022年第2期274-277,共4页Journal of Clinical Research

摘　　要：【目的】探究血管性痴呆(VD)患者血清胰岛素样生长因子-1(IGF-1)、胰岛素样生长因子结合蛋白-3(IGFBP-3)表达水平与认知损害的关系。【方法】选取2018年1月至2020年1月西电集团医院收治的63例VD患者作为VD组,根据简易智力状况量表(MMSE)评分将其分为轻度组15例、中度组26例、重度组22例;另选取同期同一医院体检健康者60例作为对照组。采用ELISA法检测受试者血清IGF-1、IGFBP-3表达水平;采用Pearson法分析VD患者血清IGF-1、IGFBP-3表达水平与蒙特利尔认知评定量表(MoCA)评分相关性;采用Logistic回归模型分析VD发生的影响因素。【结果】VD组患者血清IGF-1、IGFBP-3表达水平及MoCA评分、MMSE评分均明显低于对照组(P<0.05)。轻度组、中度组、重度组VD患者血清IGF-1、IGFBP-3表达水平依次显著降低(P<0.05)。VD患者血清IGF-1、IGFBP-3表达水平与MoCA评分呈正相关(P<0.05)。低MMSE评分、低MoCA评分及IGF-1低水平、IGFBP-3低水平是影响VD发生的危险因素(P<0.05)。【结论】VD患者血清IGF-1、IGFBP-3水平明显降低,并与其认知功能损害程度密切相关,其可作为评估VD发生的血清指标。【Objective】To investigate the expression levels of IGF-1 and IGFBP-3 in serum of patients with vascular dementia(VD)and their relationship with cognitive impairment.【Methods】From January 2018 to January 2020,63 patients with VD admitted to our hospital were selected as VD group,and they were further divided into the mild VD group(15 cases),moderate VD group(26 cases)and severe VD group(22 cases)according to Mini-mental state examination(MMSE)score.Another 60 cases of healthy volunteers without VD in our hospital during the same period were selected as normal control group.The expression levels of IGF-1 and IGFBP-3 were detected by ELISA;Pearson method was used to analyze the correlation of serum IGF-1 and IGFBP-3 expression levels with the Montreal cognitive assessment scale(MoCA)score.Logistic regression model was used to analyze the influencing factors of VD.【Results】The expression levels of serum IGF-1 and IGFBP-3,and scores of MOCA and MMSE in the VD group were lower than those in the control group(P<0.05).The levels of serum IGF-1 and IGFBP-3 in patients with VD mild group,moderate group and severe group were significantly decreased in turn(P<0.05).The expression levels of IGF-1 and IGFBP-3 were positively correlated with MoCA score(P<0.05).Low MMSE score,low MoCA score,low level of IGF-1 and low level of IGFBP-3 were risk factors for VD(P<0.05).【Conclusion】The levels of serum IGF-1 and IGFBP-3 in VD patients are significantly decreased,and they are closely related to the degree of cognitive impairment,which could be used as serum indicators to evaluate the occurrence of VD.

关 键 词：痴呆 血管性 胰岛素样生长因子Ⅰ 胰岛素样生长因子结合蛋白质3 认知 

分 类 号：R741[医药卫生—神经病学与精神病学]