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作 者:田冰心 韩军[1] 刘丙才[1] 龚昌妹 TIAN Bingxin;HAN Jun;LIU Bingcai;GONG Changmei(School of Optoelectronic Engineering,Xi'an Technological University,Xi'an 710021,China)
出 处:《光子学报》2022年第2期333-341,共9页Acta Photonica Sinica
基 金:基础科研项目(No.JCKY2018426C002)。
摘 要:近年来许多方法被提出以实现透过散射介质的聚焦和成像,然而,在非入侵且无波前整形技术的情况下,透过散射介质的目标光谱重建仍极具挑战。提出了一种非侵入式散射介质内多光谱重建的新方法。该方法通过非侵入式的探测手段,利用随机散斑照明隐藏目标,成像光谱仪记录目标的光谱信息和空间信息,并结合非负矩阵分解算法对目标混叠谱进行解析,从而实现散射介质内多光谱重建。仿真实验结果表明:该方法可以快速分辨并重建散射介质内的多个目标光谱,且重建光谱具有高的光谱相关性(大于0.99)和低的均方根误差(小于0.02)。Spectral imaging in biological tissue is an important detecting method in the biomedical field.Affected by the scattering effect of biological tissue itself,the scattered light passing through such tissues forms a group of chaotic speckles in the detector,which can not be imaged directly.Many methods have been proposed to focus and image through or in the scattering media.However,at present,it is still a challenge to realize non-invasive,non-wavefront-shaping spectral reconstruction in scattering media.Spectral intensity transmission matrix technology was first used to realize spectral retrieval from the speckle pattern through scattering media.This method requires an optical fiber spectrometer to obtain spectral information from speckle signals,although the spectral measurement system composed of multimode fiber has a high spectral resolution,its anti disturbance performance is poor,the spectral intensity transmission matrix of the fiber requires pre-calibrated,and it requires high stability of the mechanical structure.Spectral imaging can also be realized by matrix decomposition which requires a scanner to scan the pixels of the imaging surface to obtain the spectral data cube,and then compress and reconstruct it.However,the structure of the experimental system is complex.Moreover,both of these two methods can not analyze the spectra of different chemical substances through scattering media.Recently,the matrix transmission technology combined with the algorithm of the nonnegative matrix decomposition method has been proved to realize the 2D focus and imaging of fluorescent targets through the scattering medium.Although it is still unable to distinguish or retrieve the spectra of different chemicals in the scattering medium,in the case of multiple input modes,the detector receives multiple information of the target,which just provides sufficient data support for spectral analysis.Therefore,inspired by these two methods,we proposed a novel Nonnegative Matrix Factorizationbased method,combined with the multiple in
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