甲状腺疾病动物模型的研究进展  

Research progress on animal models of thyroid disease

作　　者：夏宗霄 刘海鹏 张艳娇 范源 XIA Zongxiao;LIU Haipeng;ZHANG Yanjiao;FAN Yuan(School of Traditional Chinese Medicine,Yunnan University of Chinese Medicine,Kunming 650500,China;Second Affiliated Hospital of Yunnan University of Chinese Medicine,Kunming 650216)

机构地区：[1]云南中医药大学中药学院,昆明650500 [2]云南中医药大学第二附属医院,昆明650216

出　　处：《中国比较医学杂志》2022年第2期87-93,共7页Chinese Journal of Comparative Medicine

基　　金：国家自然科学基金地区基金项目(81360652);云南省科技厅科技计划项目-应用基础研究计划(202101AZ010001-015);云南省万人计划“名医”专项;云南省高校中西医结合防治甲状腺病重点实验室项目。

摘　　要：甲状腺疾病是一种临床上常见的内分泌疾病,其病因机制复杂多样。目前关于甲状腺疾病的研究主要局限于临床上的药效评价,对其发病机制研究较少,因此甲状腺疾病动物模型的建立对分析该类疾病的病理机制以及提高临床疗效有着较为重要的意义,成功的实验动物模型不仅能降低实验成本,还具有可行性、重复性高等特点。本文就近年来关于甲状腺功能减退症、甲状腺功能亢进症、桥本甲状腺炎、甲状腺癌等甲状腺疾病动物模型的建立方法做一总结归纳,并对各类模型的优缺点进行分析,为相关实验的开展提供理论依据。Thyroid disease is a common endocrine system disease,and its etiology is complex and diverse.At present,research on thyroid diseases is mainly limited to the evaluation of clinical efficacy of drugs with few studies on the pathogenesis of this disease.Therefore,it is important to establish animal models of thyroid diseases for analyzing pathological mechanisms and improving the clinical efficacy of disease treatment.A successful experimental animal model can not only increase disease samples in a short period of time with low cost but also avoid harm to the human body.Furthermore,animal models have the advantage of stability.This review summarizes the method used to establish animal models of thyroid diseases in recent years,such as those for hypothyroidism,hyperthyroidism,hashimoto’s thyroiditis,and thyroid cancer,and analyzes the advantages and disadvantages of various models to provide a theoretical basis for the development of related experiments.

关 键 词：甲状腺疾病 药物 核酸免疫 转基因 动物模型 

分 类 号：R-33[医药卫生]