肝纤维化小鼠模型研究现状  

Current status of research on mice models of liver fibrosis

作　　者：王娟[1,2] 杨晶晶[1] 周仁鹏[1,2] 胡伟 鲁超[2,3] WANG Juan;YANG Jingjing;ZHOU Renpeng;HU Wei;LU Chao(Department of Clinical Pharmacology,the Second Hospital of Anhui Medical University,Hefei 230601,China;School of Pharmacy,Anhui Medical University,Hefei 230032;Anhui University of Science&Technology,Huainan 232001)

机构地区：[1]安徽医科大学第二附属医院药物临床试验研究中心,合肥230601 [2]安徽医科大学药学院,合肥230032 [3]安徽理工大学,安徽淮南232001

出　　处：《中国比较医学杂志》2022年第2期105-110,共6页Chinese Journal of Comparative Medicine

基　　金：国家自然科学基金(81600477)。

摘　　要：肝纤维化是肝病领域研究的热点问题,其模型的制备有助于探究发病机理。本论文综述了目前报道的十种常用的肝纤维化小鼠模型,讨论了各自模型的成模原理、造模途径、模型效果、优缺点和用途,比较不同小鼠模型的异同,旨在为模型的选择提供依据,为肝纤维化的研究方向提供参考。Liver fibrosis is an important topic in the field of liver disease research,and the establishment of animal models for liver fibrosis is key to exploring the pathogenesis of this disease.This article summarizes the ten commonly used types of mice models of liver fibrosis and discusses their respective mechanisms,Methods of establishment,effects,and advantages and disadvantages of establishing a particular mice model.The differences and similarities between the models are compared to provide a reference for the selection of an appropriate model for liver fibrosis research.

关 键 词：肝纤维化 小鼠 动物模型 

分 类 号：R-33[医药卫生]