浅述干细胞治疗慢性肾疾病的潜力  

A brief review on the development of stem cells as therapeutics for chronic kidney disease

作　　者：蒋超[1] 王超[1] 任晓楠[1] 周晓辉[1] JIANG Chao;WANG Chao;REN Xiaonan;ZHOU Xiaohui(Shanghai Public Health Clinical Center,Fudan University,Shanghai 201508,China)

机构地区：[1]复旦大学附属公共卫生临床中心,上海201508

出　　处：《中国比较医学杂志》2022年第2期138-144,共7页Chinese Journal of Comparative Medicine

基　　金：上海市科学技术委员会实验动物专项(19140905301);上海市卫生健康委员会项目(20204Y0335);上海市公共卫生临床中心院级科研课题(KY-GW-2021-05,KY-GW-2021-38);上海实验动物安全控制管理信息平台研究及应用示范(21140900200);生物安全实验室实验动物信息可追溯系统应用评价研究(21140900202)。

摘　　要：慢性肾疾病具有高发病率、高致死率的特点并且在全球范围内流行,但除了血液透析和肾移植外,迄今尚无其他有效方法治愈,因此是当前严重危害人类生命健康的重大疾病之一。干细胞是一类具有自我更新和分化为多种谱系能力的细胞,近年来研究提示,干细胞具有作为慢性肾疾病潜在治疗方法的可能。本文对间充质干细胞、胚胎干细胞和诱导多潜能干细胞三种干细胞在治疗慢性肾疾病方面的潜力进行了一个简要综述。Chronic kidney disease(CKD)is prevalent worldwide and represents a serious threat to human life and health with a high morbidity and mortality.Currently,there are no effective curative therapeutics for CKD except hemodialysis and renal transplantation.Stem cells,which are able to self-renew and differentiate into multiple lineages,have been explored as a potentially viable treatment for CKD in recent years.In this review,the potential applications of three types of stem cells for treatment of CKD are briefly summarized,including embryonic stem cells,induced pluripotent stem cells,and mesenchymal stem cells.

关 键 词：慢性肾疾病 间充质干细胞 胚胎干细胞 诱导多潜能干细胞 

分 类 号：R-33[医药卫生]