三七皂苷-壳聚糖共凝胶的制备及表征  

Preparation and Characterization of Aldehyde Cross-linked Chitosan Hydrogel-Panax Notoginseng Saponin Inclusion Compound

作　　者：丁萌 李胜男 董翠芳[1] 刘树恒[1] DING Meng;LI Sheng-nan;DONG Cui-fang;LIU Shu-heng(Department of Chemistry and Chemical Engineering,Cangzhou Normal University,Cangzhou,Hebei 061001,China)

机构地区：[1]沧州师范学院化学与化工系,河北沧州061001

出　　处：《沧州师范学院学报》2022年第1期14-18,共5页Journal of Cangzhou Normal University

基　　金：2019年河北省高等学校科学技术研究项目(青年拔尖人才项目)“天然抗卵巢癌PARP抑制剂先导化合物的发现及构效关系研究”,编号:BJ2020207;2019年沧州师范学院科研创新团队(重点团队)“天然产物研究与功能材料创新团队”,编号:cxtdl1901;2020年沧州市科技支撑计划项目(一般项目)“盐碱地资源中真菌次级代谢产物系统分离研究”,编号:204203006.

摘　　要：通过共凝胶和机械混合两种方法分别制备了三七皂苷-壳聚糖(PNS-CSB)共凝胶和机械混合物,利用红外光谱(FT-IR)、紫外光谱(UV)、X-射线衍射(XRD)、扫描电子显微镜(SEM)、热重分析(TG)等对其结构、性能进行表征.FT-IR光谱表征表明,三七皂苷(PNS)通过物理作用包埋在壳聚糖水凝胶(CSB)中;SEM和XRD表征发现,通过共凝胶,PNS较好地分散到CSB凝胶网络中;通过机械混合,PNS结晶出现分相现象;TG表征表明,PNS-CSB共凝胶具有更好的热稳定性.PNS-CSB共凝胶可作为PNS药物载体,为开发PNS的缓释制剂提供理论指导.ThePanax notoginseng saponins(PNS)chitosan co-gelation and mechanical mixtures were prepared by co-gelation and mechanical mixing.Its structure and properties were characterized by FT-IR,UV,XRD,SEM and TG.FT-IR spectra showed that PNS was embedded in chitosan hydrogel(CSB)by physical action.SEM and XRD showed that PNS could be well dispersed in the gel network of CSB.Through mechanical mixing,PNS crystallization appears phase separation.TG characterization showed that PNS-CSB co-gelation had better thermal stability.PNS-CSB co-gelation can be used as PNS drug carrier to provide theoretical guidance for developing PNS sustained-release preparations.

关 键 词：三七皂苷 壳聚糖水凝胶 共凝胶 机械混合 表征 

分 类 号：R914.4[医药卫生—药物化学] TQ463[医药卫生—药学]