Ophthalmic manifestations of Cryptococcus gattii species complex:a case series and review of the literature  

作　　者：Grace A.McCabe Jack W.McHugh Todd Goodwin Douglas F.Johnson Anthony Fok Thomas G.Campbell 

机构地区：[1]Department of Ophthalmology,the Royal Melbourne Hospital,Melbourne,Victoria 3050,Australia [2]Department of Internal Medicine,Mayo Clinic,Rochester,Minnesota 55902,USA [3]James Cook University,Townsville,Queensland 4811,Australia [4]NQ Eye Foundation,Townsville,Queensland 4811,Australia [5]Department of Infectious Disease,the Royal Melbourne Hospital,Melbourne,Victoria 3050,Australia [6]Department of Neurology,the Royal Melbourne Hospital,Melbourne,Victoria 3050,Australia [7]Centre for Eye Research Australia,East Melbourne,Victoria 3002,Australia [8]Ophthalmology,Department of Surgery,the University of Melbourne,Melbourne,Victoria 3010,Australia

出　　处：《International Journal of Ophthalmology(English edition)》2022年第1期119-127,共9页国际眼科杂志（英文版）

基　　金：Campbell TG received support from the Hector Maclean Scholarship through the Centre for Eye Research Australia and Department of Surgery,University of Melbourne,Australia。

摘　　要：AIM:To report 4 cases of Cryptococcus gattii(C.gattii)species complex infection with diverse ophthalmic manifestations,and to review the literature to examine pathobiology of disease,classical ophthalmic presentations and outcomes,and treatment modalities for this emerging pathogen.METHODS:Cases of C.gattii meningoencephalitis with ophthalmic manifestations were identified via chart review at two institutions in Australia and one institution in the mid-west region of the United States and are reported as a case series.Additionally,a MEDLINE literature review was conducted to identify all reported cases of C.gattii with ophthalmic manifestations from 1990-2020.Cases were reviewed and tabulated,together with our series of patients,in this report.RESULTS:Four cases of C.gattii with ophthalmic manifestations are presented;three from Australia and one from the USA.A literature review identified a total of 331 cases of C.gattii with visual sequelae.The majority of cases occurred in immunocompetent individuals.Blurred vision and diplopia were the most common presenting symptoms,with papilloedema the most common sign,reported in 10%-50%of cases.Visual loss was reported in 10%-53%of cases,as compared to rates of visual loss of 1%-9%in C.neoformans infection.Elevated intracranial pressure,cerebrospinal fluid(CSF)fungal burden,and abnormal neurological exam at presentation correlated with poor visual outcomes.The mainstays of treatment are anti-fungal agents and aggressive management of intracranial hypertension with serial lumbar punctures.CSF diversion procedures should be considered for refractory cases.Acetazolamide and mannitol are associated with high complication rates,and adjuvant corticosteroids have demonstrated higher mortality rates;these treatments should be avoided.CONCLUSION:Permanent visual loss represents a devastating yet potentially preventable sequelae of C.gattii infection.Intracranial hypertension needs to be recognised early and aggressively managed.Referral to an ophthalmologist/neuro-ophthalmologist

关 键 词：CRYPTOCOCCUS Cryptococcus gattii CRYPTOCOCCOSIS ophthalmic manifestation 

分 类 号：R519.4[医药卫生—内科学] R771[医药卫生—临床医学]