BACKGROUND Worldwide,there has been a steady increase in the number of cases of pulmonary cryptococcosis diagnosed in immunocompetent patients,where symptoms can range from mild to severe.Clinical and radiological dis...
Supported by Shenzhen Fund for Guangdong Provincial High-Level Clinical Key Specialties,No.SZGSP012;Shenzhen Key Medical Discipline Construction Fund,No.SZXK032。
BACKGROUND Cryptococcus is a systemic opportunistic pathogenic fungus that can cause infections in both immunocompromised and immunocompetent hosts,with diverse clinical manifestations,ranging from asymptomatic pulmon...
Background: Cryptococcus neoformans is an opportunistic fungal pathogen that primarily affects immunocompromised individuals. While traditional histologic methods such as hematoxylin and eosin (H&E) staining can somet...
supported by the Tianjin Key Medical Discipline(Specialty)Construction Project(Grant No.TJYXZDXK-007A);the China International Medical Foundation Project(Grant No.Z-2021-15-18);Tianjin Health Technology Project(Grant No.20188).
Chronic liver diseases,including primary biliary cholangitis(PBC),are recognized as immunosuppressive conditions due to the impaired functionality of hepatic sinusoidal Kupffer cells.[1]PBC is specifically characteriz...
The fungal community associated with beach sand and plants located along marine coasts are an under-studied area of research despite its potential relevance to human health. In this study, we isolated and identified t...
This work was supported by the grants from the General Program of the National Natural Science Foundation of China(No.82370005);the National Key Research and Development Program(No.2021YFC2302100);the Capital Health Development Scientific Research Unit Matching Fund(No.2020-2Z-2086);the Beijing Hospitals Authority Clinical Medicine Development of Special Funding Support(No.XMLX202115);the National Capacity Building Project for Multidisciplinary Diagnosis and Treatment of Major Diseases(No.2019YLFW);the Beijing Key Clinical Specialty Project(No.2020ZDZK1);the National Key Research and Development Program(No.2020YFC2005404).
Cryptococcus gatti(Cg)is a facultative intracellular pathogen that can replicate and disseminate in mammalian macrophages,causing life-threatening cryptococcosis in both immunocompetent and immunocompromised in-dividu...
Cryptococcus is a yeast typically found in bird feces such as pigeon droppings. Infection may occur through inhalation of spores or via direct inoculation into the skin. Typically there is a history of immunosuppressi...
This case report presents an unusual and challenging diagnostic scenario involving a 72-year-old man who recently returned from a trip to Maui, Hawaii. While in Maui, the patient presented with a fever and fatigue tha...
the National Key Research and Development Program(No.2021YFC2302100);the National Key Research and Development Program(No.2020YFC2005404);the Beijing Key Clinical Specialty Project(No.2020ZDZK1);the National Capacity Building Project for Multidisciplinary Diagnosis and Treatment of Major Diseases(No.2019YLFW);the Capital Health Development Scientific Research Unit Matching Fund(No.2020-2Z-2086);the“Sailing”Plan for Clinical Technology Innovation Project in Beijing(No.XMLX202115).
Few therapeutic drugs and increased drug resistance have aggravated the current treatment difficulties of Cryptococcus in recent years.To better understand the antifungal drug resistance mechanism and treatment strate...
supported by the National Key Research and Development Program of China(2021YFC2300400)[Linqi Wang],2021YFC230000[Linqi Wang],2021YFA0911300[Xiao Liu],2021YFC2100600[Xiuyun Tian]:Major Infections Diseases Such as AIDS and Viral Hepatitis Prevention and Control Technology Major Projects(2018ZX10101003[Ying Yang]);and CAS Interdisciplinary Innovation Team(Linqi Wang).
Cryptococcus neoformans and its sister species Cryptococcus deuterogattii are important human fungal pathogens.Despite their phylogenetically close relationship,these two Cryptococcus pathogens are greatly different i...