Cryptococcus splenic abscess in primary biliary cholangitis: a case report  

作　　者：Yuxin Dong Qing Tang Lijun Wang Songtao Shou 

机构地区：[1]Department of Emergency Medicine,Tianjin Medical University General Hospital,Tianjin 300052,China

出　　处：《World Journal of Emergency Medicine》2024年第4期319-321,共3页世界急诊医学杂志（英文）

基　　金：supported by the Tianjin Key Medical Discipline(Specialty)Construction Project(Grant No.TJYXZDXK-007A);the China International Medical Foundation Project(Grant No.Z-2021-15-18);Tianjin Health Technology Project(Grant No.20188).

摘　　要：Chronic liver diseases,including primary biliary cholangitis(PBC),are recognized as immunosuppressive conditions due to the impaired functionality of hepatic sinusoidal Kupffer cells.[1]PBC is specifically characterized by cholangitis and progressive liver pathology,which may eventually lead to cirrhosis.The compromised liver function and reduced efficacy of Kupffer cells in patients with PBC weaken their cell-mediated immune responses,increasing their susceptibility to opportunistic pathogens such as Cryptococcus.[2]Cryptococcosis is an infectious disease caused by pathogenic encapsulated yeasts of the genus Cryptococcus,which is distributed worldwide and exhibits diverse clinical presentations.[3]Most case reports on cryptococcal infections are associated with HIV infection or other conditions that compromise the immune system.[4]Case reports related to primary biliary cholangitis are rare.Therefore,this case report underscores a rare cryptococcal infection in a patient with primary biliary cholangitis,emphasizing the need to consider opportunistic infections in those with compromised liver function and immune dysregulation.

关 键 词：CHOLANGITIS IMPAIRED DISEASES 

分 类 号：R575.7[医药卫生—消化系统] R551.1[医药卫生—内科学]