多巴丝肼片联合盐酸普拉克索二联疗法对血管源性帕金森综合征患者GSH、CAT、T-SOD、UPDRS评分的影响  

Effect of Levodopa and Benserazide Hydrochloride Tablets Combined with Pramipexole Dihydrochloride Sustained Release Tablets on GSH, CAT, T-SOD, UPDRS Scores in Patients with Vasogenic Parkinson Syndrome

作　　者：刘媛媛[1] LIU Yuanyuan(Tieling City Central Hospital,Liaoning Province,Tieling 112000,China)

机构地区：[1]辽宁省铁岭市中心医院,辽宁铁岭112000

出　　处：《中国医学创新》2022年第3期45-48,共4页Medical Innovation of China

摘　　要：目的:研究多巴丝肼片联合盐酸普拉克索二联疗法对血管源性帕金森综合征(VP)患者谷胱甘肽(GSH)、过氧化氢酶(CAT)、总超氧化物歧化酶(T-SOD)以及帕金森综合评分量表(UPDRS)评分的影响。方法:将2018年3月-2020年3月铁岭市中心医院收治的91例VP患者纳入研究,将其以电脑随机数字表法分为二联组45例和常规组46例。常规组开展多巴丝肼片治疗,二联组则实施多巴丝肼片联合盐酸普拉克索治疗。分析两组临床疗效,治疗前后血清GSH、CAT、T-SOD水平,治疗前后UPDRS评分,以及不良反应发生情况。结果:二联组治疗总有效率高于常规组(P<0.05)。治疗后,二联组血清GSH、CAT、T-SOD水平均高于常规组(P<0.05)。治疗后,二联组各项UPDRS评分均低于常规组(P<0.05)。两组嗜睡、体位性低血压、视幻觉发生率比较,差异均无统计学意义(P>0.05)。结论:多巴丝肼片与盐酸普拉克索二联疗法治疗VP患者的临床效果显著,可明显改善机体氧化应激反应,减轻临床症状。Objective:To study the effects of Levodopa and Benserazide Hydrochloride Tablets combined with Pramipexole Dihydrochloride Sustained Release Tablets on glutathione (GSH),catalase (CAT),total superoxide dismutase (T-SOD) and Parkinson comprehensive rating scale (UPDRS) in patients with vascular Parkinson syndrome (VP).Method:A total of 91 patients with VP admitted to Tieling City Central Hospital from March 2018 to March 2020 were included in this study,and they were divided into 45 cases in the double therapy group and 46 cases in the conventional group by computer random number table method.The conventional group was treated with Levodopa and Benserazide Hydrochloride Tablets,and the double therapy group was treated with Levodopa and Benserazide Hydrochloride Tablets combined with Pramipexole Dihydrochloride Sustained Release Tablets.Clinical efficacy,serum GSH,CAT and T-SOD levels before and after treatment,UPDRS score before and after treatment,and incidence of adverse reactions were analyzed.Result:The total effective rate of the double therapy group was higher than that of the conventional group (P<0.05).After treatment,the levels of serum GSH,CAT and T-SOD in the double therapy group were higher than those in the conventional group (P<0.05).After treatment,the UPDRS scores of the double therapy group were lower than those of the conventional group (P<0.05).There were no significant differences in the incidence of drowsiness,postural hypotension and visual hallucination between the two groups (P>0.05).Conclusion:The combined therapy of Levodopa and Benserazide Hydrochloride Tablets and Pramipexole Dihydrochloride Sustained Release Tablets has a significant clinical effect in the treatment of patients with VP,it can significantly improve the body’s oxidative stress response and reduce clinical symptoms.

关 键 词：血管源性帕金森综合征 多巴丝肼片 盐酸普拉克索 帕金森综合评分量表 氧化应激反应 

分 类 号：R742.5[医药卫生—神经病学与精神病学]