IA期乳腺癌患者中医证候分型特点及预后的相关影响因素分析  

Analysis of traditional Chinese medical science syndrome types and prognostic factors in patients with stage IA breast cancer

作　　者：阎慧君[1] 李戈[1] Yan Huijun;Li Ge(The Fourth Department of Internal Medicine,Dalian Hospital of Traditional Chinese Medicine,Dalian 116000,Liaoning,China)

机构地区：[1]大连市中医医院内四科,辽宁大连116000

出　　处：《贵州医药》2022年第3期349-351,共3页Guizhou Medical Journal

摘　　要：目的分析IA期乳腺癌患者中医证候分型特点及预后的相关影响因素。方法选取IA期乳腺癌患者100例,分析其中医证候分型特点,并对其临床资料进行单因素分析,对其中差异有统计学意义的因素进行多因素Logistic回归分析。结果IA期乳腺癌患者的中医证候分型中痰毒蕴结占比最大。IA期乳腺癌患者5年随访期间共有2例死亡,有21例发生复发/转移。其中,IA期乳腺癌患者中组织学分级为Ⅲ级者5年PFS为56.76%,低于组织学分级Ⅰ级(100.00%)、Ⅱ级(92.16%)者;有淋巴脉管癌栓者5年PFS为61.22%,低于无淋巴脉管癌栓者(96.08%);Ki-67高表达者5年PFS为72.06%,低于Ki-67低表达者(93.75%);临床分期为T_(1mic)~T_(1a)期者5年PFS为100.00%,高于临床分期为T_(1b)期(75.00%)、T_(1c)期(72.00%)者,差异均有统计学意义(P<0.05)。经多因素Logistic回归分析结果显示,组织学分级为Ⅲ级、Ki-67高表达、临床分期为T_(1b)、T_(1c)期为影响IA期乳腺癌患者预后的独立危险因素(P<0.05)。结论IA期乳腺癌患者以痰毒蕴结型占比最高,且组织学分级、Ki-67表达水平、临床分期均会影响患者预后,临床可据其予以有效的中西医干预措施以改善患者预后。Objective To analyze the characteristics of Traditional Chinese Medical(TCM)science syndrome types,and relate influencing factors of prognosis in patients with stage IA breast cancer.Methods A total of 100 patients with stage IA breast cancer who were admitted to the Fourth Departments of Dalian Hospital of Traditional Chinese Medicine were selected retrospectively as the research subjects from January 2010 to December 2015,and the characteristics of TCM syndrome types were analyzed.According to the clinical data of stage IA breast cancer patients collected from the electronic medical record system of Dalian Hospital of Traditional Chinese Medicine,the single factor analysis was performed on the clinical data of two groups,and the multi-factor Logistic regression analysis was performed on the factors with statistically significant differences.Results The TCM syndrome type of stage IA breast cancer patients has the largest proportion of phlegm toxin accumulation.During the 5-year follow-up,2 patients died and 21 patients had recurrence/metastasis.Among them,the 5-year PFS of patients with stage IA breast cancer with histological gradeⅢwas 56.76%,which was lower than those with histological gradeⅠ(100.00%)andⅡ(92.16%).The 5-year PFS of patients with lymphatic vessel tumor thrombus was 61.22%,which was lower than that of patients without lymphatic vessel tumor thrombus(96.08%).The 5-year PFS of high expression of Ki-67 was 72.06%,which was lower than that of low expression of Ki-67(93.75%).The 5-year PFS of patients with clinical stage T_(1mic)~T_(1a) was 100.00%,which was significantly higher than that of patients with clinical stage T_(1b)(75.00%)and T_(1c)(72.00%)(P<0.05).Multivariate Logistic regression analysis showed that histological gradeⅢ,high expression of Ki-67,clinical stages T_(1b) and T_(1c) were independent risk factors affecting the prognosis of patients with stage IA breast cancer,with significant difference(P<0.05).Conclusion The type of phlegm toxin accumulation accounts for the highest pr

关 键 词：乳腺癌 IA期 中医证候 预后 影响因素 

分 类 号：R737.9[医药卫生—肿瘤]