饮用水中新型环状消毒副产物的毒性研究进展  

Research Progress on Toxicity of New Cyclic Disinfection Byproducts in Drinking Water

作　　者：魏文哲 罗家怡 赵佳焱 楚文海[2] 董慧峪 周庆[1] 施鹏 潘旸[1] Wei Wenzhe;Luo Jiayi;Zhao Jiayan;Chu Wenhai;Dong Huiyu;Zhou Qing;Shi Peng;Pan Yang(State Key Laboratory of Pollution Control and Resource Reuse,School of the Environment,Nanjing University,Nanjing 210023,China;State Key Laboratory of Pollution Control and Resource Reuse,College of Environmental Science and Engineering,Tongji University,Shanghai 200092,China;Key Laboratory of Drinking Water Science and Technology,Research Center for Eco-Environmental Sciences,Chinese Academy of Sciences,Beijing 100085,China)

机构地区：[1]污染控制与资源化国家重点实验室,南京大学环境学院,南京210023 [2]污染控制与资源化国家重点实验室,同济大学环境科学与工程学院,上海200092 [3]中国科学院饮用水科学与技术重点实验室,中国科学院生态环境研究中心,北京100085

出　　处：《生态毒理学报》2021年第6期87-103,共17页Asian Journal of Ecotoxicology

基　　金：国家自然科学基金面上项目(51778280,52070093);江苏省优秀青年基金资助项目(BK20180058)。

摘　　要：饮用水中新型环状消毒副产物(disinfection byproducts,DBPs)因具有较高的生物毒性,受到越来越广泛的关注。本文简要概述了国内外饮用水中新型环状DBPs检测情况及暴露水平,重点探讨了新型环状DBPs的细胞毒性、遗传毒性和内分泌干扰效应,并总结了定量构效关系(quantitative structure-activity relationship,QSAR)在毒性效应预测方面的应用,旨在为新型环状DBPs的毒性及致毒机理研究提供理论参考。New cyclic disinfection byproducts(DBPs)in drinking water have been intensively attracting concerns due to their significantly greater toxicity than commonly known DBPs.This paper briefly reviewed the detection and occurrence of new cyclic DBPs in drinking water,and discussed cytotoxicity,genotoxicity,and endocrine disrupting effect of these new cyclic DBPs in detail.The application of quantitative structure-activity relationship(QSAR)in toxicity prediction was also summarized.This review aimed to provide a theoretical reference for further toxicity and mechanism studies of new cyclic DBPs.

关 键 词：新型环状消毒副产物 饮用水 毒性 QSAR 

分 类 号：X171.5[环境科学与工程—环境科学]