89例自身免疫性脑炎患者临床特征分析  

Clinical features of 89 patients with autoimmune encephalitis

作　　者：张艳芳 吕虹[1] 邵春青[1] 刘紫薇 张国军[1] ZHANG Yanfang;LYV Hong;SHAO Chunqing;LIU Ziwei;ZHANG Guojun(Laboratory of Beijing Tiantan Hospital,Capital Medical University/Key Laboratory for Quality Control of In Vitro Diagnostics of NMPA/Beijing Engineering Research Center of Immunological Reagents Clinical Research,Beijing 100070,China)

机构地区：[1]首都医科大学附属北京天坛医院实验诊断中心/国家药监局体外诊断试剂质量控制重点实验室/北京市免疫试剂临床工程技术研究中心,北京100070

出　　处：《国际检验医学杂志》2022年第6期692-694,700,共4页International Journal of Laboratory Medicine

基　　金：北京市医院管理中心重点医学专业发展计划(ZYLX202108)。

摘　　要：目的探讨自身免疫性脑炎(AE)的临床特征及鞘内免疫球蛋白G(IgG)等相关实验室指标在AE诊断中的意义。方法选择2016年1月至2021年4月该院收治的89例AE患者为研究对象,分析患者的性别、年龄、抗体类型。结果AE患者年龄3~80岁,以成年人为主(82.0%)。89例患者脑脊液中均检测出抗体,抗体阳性率达100.00%;24例患者血清检测出抗体,抗体阳性率为58.54%,差异有统计学意义(P=0.001)。IgG 24 h鞘内合成率(IgGSR)异常组IgGSR显著高于IgGSR正常组,差异有统计学意义(P<0.05)。IgGSR异常组脑脊液IgG水平、血清IgG水平均高于IgGSR正常组,差异有统计学意义(P<0.05)。结论了解AE的疾病特征和IgGSR等实验室指标分析有助于该病的诊断和改善AE患者的预后。Objective To investigate clinical features of autoimmune encephalitis(AE)and the significance of laboratory indicators related to intrathecal immunoglobulin G(IgG)synthesis in the diagnosis of AE.Methods A total of 89 hospitalized patients with AE were collected as the subjects,and genders,ages,and antibody types of patients were analyzed.Results AE patients aged 3-80 years,adults were dominated(82.0%).Antibody in cerebrospinal fluid were all positive(100.00%),and antibodies were detected in the serum of 24 patients(58.54%),differences were statistically significant(P=0.001).The 24 h intrathecal IgG synthesis rate(IgGSR)in abnormal IgGSR group was significantly higher than that of normal IgGSR group(P<0.05).Levels of IgG in cerebrospinal fluid and serum of abnormal IgGSR group were significantly higher than that of normal IgGSR group(P<0.05).Conclusion Understanding the epidemiological characteristics of AE and the analysis of laboratory indicators of 24 h IgG synthesis rate can help improve the diagnosis and the prognosis of AE patients.

关 键 词：自身免疫性脑炎 自身抗体 流行病 回顾性分析 

分 类 号：R742.6[医药卫生—神经病学与精神病学]