南京地区体检人群胃蛋白酶原表达水平和意义  

The expression level and significance of serum pepsinogen in some examination population in Nanjing

作　　者：刘艳秋[1] 陈家慧[1] 王琼琼 何萍[1] 王坤 立彦[1] LIU Yanqiu;CHEN Jiahui;WANG Qiongqiong;HE Ping;WANG Kun;LI Yan(Department of Nuclear Medicine,Nanjing First Hospital/Nanjing Hospital Affiliated of Nanjing Medical University,Nanjing,Jiangsu 210006,China;Shenzhen New Industries Biomedical Engineering Co.,Ltd.,Shenzhen,Guangdong 518000,China)

机构地区：[1]南京医科大学附属南京医院/南京市第一医院核医学科,江苏南京210006 [2]深圳市新产业生物医学工程股份有限公司,广东深圳518000

出　　处：《国际检验医学杂志》2022年第6期730-733,共4页International Journal of Laboratory Medicine

摘　　要：目的探讨南京地区部分健康体检人群血清胃蛋白酶原(PG)的表达水平和意义。方法选取南京地区4192例体检者进行检查,采用化学发光方法定量检测血清中PGⅠ、PGⅡ、PGⅠ/PGⅡ(PGR),计算中位数和95%置信区间。结果男性PGⅠ、PGⅡ水平均高于女性,差异有统计学意义(P<0.01);而女性的PGR要高于男性,差异有统计学意义(P<0.01)。男性、女性PGⅠ、PGⅡ水平随着年龄的增长而逐渐增加,PGR随着年龄增长逐渐降低。结论体检人群中,血清PG水平受到性别、年龄的因素影响,判断结果时应采用不同的参考范围,以免出现误判。Objective To investigate the expression and significance of serum pepsinogen(PG)in healthy examination population in Nanjing.Methods A total of 4192 of physical examiners of Nanjing areas were selected as subjects.Chemiluminescent Immunoassay method was used to quantitatively detect serum PGⅠ,PGⅡand PGⅠ/PGⅡ(PGR)levels.The median and 95%confidence interval were calculated.Results After comparing the detection levels of PGⅠ,PGⅡand PGR of different genders,it was found that the detection levels of PGⅠand PGⅡin men were higher than those in women,and the differences were statistically significant(P<0.01),while the PGR detection results of women were higher than those of men,and the differences were statistically significant(P<0.01).The detection value of PGⅠand PGⅡin both male and female were gradually increased with age,and PGR levels showed a decreasing trend with age.Conclusion In health examination population,serum PG will be affected by factors such as gender and age.When judging the result,it should be carried out in a different range to avoid misjudgment.

关 键 词：胃蛋白酶原 体检人群 影响因素 

分 类 号：R735.2[医药卫生—肿瘤]