急性缺血性脑卒中患者颈动脉粥样硬化与肾小球滤过率的关系  

Relationship between Carotid Atherosclerosis and Glomerular Filtration Rate in Patients with Acute Ischemic Stroke

作　　者：翁羽 马铁梁[1] 储虹[1] 胡鹏华[1] 任占云[1] 赵彦平[1] WENG Yu;MA Tieliang;CHU Hong(The Affiliated Yixing Hospital of Jiangsu University,Jiangsu 214200,China)

机构地区：[1]江苏大学附属宜兴医院,214200

出　　处：《医学研究杂志》2022年第3期95-98,117,共5页Journal of Medical Research

基　　金：江苏省无锡市首届双百人才计划项目(BJ2020105)。

摘　　要：目的探讨急性缺血性脑卒中(acute ischemic stroke,AIS)患者颈动脉粥样硬化与肾小球滤过率(glomerular filtration rate,GFR)水平的关系。方法选取2020年10月~2021年4月于笔者医院神经内科首次入院治疗的AIS患者217例,根据颈动脉超声结果分为颈动脉正常组(73例),颈动脉粥样硬化组(144例),探讨AIS患者颈动脉粥样硬化与GFR的关系。结果颈动脉粥样硬化组GFR水平低于颈动脉正常组,差异有统计学意义(P<0.05)。Logistic回归分析显示,GFR降低是AIS患者颈动脉粥样硬化的独立危险因素(P<0.05)。ROC曲线分析显示GFR评估AIS患者颈动脉粥样硬化与否的曲线下面积为0.774(95%CI:0.712~0.836,P<0.001)。结论AIS患者GFR水平与颈动脉粥样硬化呈负相关,GFR水平下降是AIS患者发生颈动脉粥样硬化的危险因素,有望作为临床上评估AIS患者颈动脉粥样硬化的重要指标。Objective To investigate the relationship between carotid atherosclerosis and glomerular filtration rate(GFR)level in patients with acute ischemic stroke(AIS).Methods A total of 217 AIS patients hospitalized for the first time in the department of Neurology of our hospital from October 2020 to April 2021 were enrolled and divided into normal carotid artery group(n=73)and atherosclerosis group(n=144)according to carotid artery ultrasound results,to explore the relationship between carotid atherosclerosis and GFR in AIS patients.Results The GFR of carotid atherosclerosis group was lower than that of normal carotid artery group,and the difference was statistically significant(P<0.05).Univariate Logistic regression analysis showed that age(OR=0.995),history of hypertension(OR=1.973),GFR(OR=0.909)were correlated with carotid atherosclerosis(P<0.05).Multivariate Logistic regression analysis showed that age and GFR reduction were independent risk factors for carotid atherosclerosis in AIS patients(P<0.05).ROC analysis showed that the area under the curve of GFR for determining carotid atherosclerosis in AIS patients was 0.774(95%CI:0.712-0.836,P<0.001).Conclusion With the aggravation of carotid atherosclerosis,GFR decreases,which is a risk factor for carotid atherosclerosis in AIS patients and can be used as an important clinical indicator for evaluating carotid atherosclerosis in AIS patients.

关 键 词：急性缺血性脑卒中 颈动脉粥样硬化 肾小球滤过率 

分 类 号：R743.3[医药卫生—神经病学与精神病学]