小分子亮氨酸重复蛋白聚糖家族在维持角膜透明性中的作用  

Effects of small leucine-rich proteoglycans on corneal transparency

作　　者：韩涵(综述) 何宇茜[1] 张妍(审校)[1] Han Han;He Yuxi;Zhang Yan(Department of Corneal Refraction,Eye Center,The Second Hospital of Jilin University,Changchun 130041,China)

机构地区：[1]吉林大学第二医院眼科中心角膜屈光科,长春130041

出　　处：《中华实验眼科杂志》2022年第3期266-270,共5页Chinese Journal Of Experimental Ophthalmology

基　　金：吉林省医疗卫生人才专项项目(2019SCZT057);吉林省科技厅自然科学基金项目(20180101146JC);吉林省财政厅青年人才培养项目(3D5197389429);吉林省中医药科技资助项目(2019134);吉林省科技厅国际科技合作项目(20200801016GH);吉林大学优秀青年教师培养计划项目(419080500586、419080520252)。

摘　　要：小分子亮氨酸重复蛋白聚糖(SLRPs)为角膜的重要结构成分,在角膜透明性的形成和维持方面发挥重要作用。SLRPs大量分布于角膜基质层中,主要分为Ⅰ型、Ⅱ型和Ⅲ型。各成员之间存在补偿性和协同性作用,共同调控基质层胶原纤维的形成和装配,维持胶原纤维排列的高度有序性,奠定角膜透明性的基础。Decorin和lumican分别是Ⅰ型和Ⅱ型SLRPs的主要功能成分,二者基因表达改变或核心蛋白结构异常均会影响角膜基质层其他细胞外基质成分的正常含量和排列关系,导致胶原纤维的形成、装配和排列异常,造成角膜混浊。SLRPs可通过结合促纤维化细胞因子及其受体等调控角膜创伤修复和基质重塑,为治疗角膜疾病和研究角膜透明性的分子机制提供依据。本文就SLRPs家族成员生物学活性及其在角膜透明性中的作用研究进展进行综述。Small leucine-rich proteoglycans(SLRPs)are necessary structural ingredients of the cornea,which are vital for the establishment and maintenance of corneal transparency.SLRPs are mainly located in the corneal stroma and can be divided into classⅠ,classⅡ,and classⅢ.The compensatory and cooperative interactions among SLRPs regulate the formation and assembly of stromal collagen fibrils,thereby maintaining the highly ordered arrangement of collagen fibrils,and establishing corneal transparency.Decorin and lumican are the main functional components of classⅠand classⅡSLRPs,respectively,and changes in their expression or abnormities in the structure of their core proteins affect the natural content and arrangement of other stromal extracellular matrix components,ultimately resulting in abnormal fibril formation,assembly,and arrangement,causing corneal opacity.SLRPs can regulate corneal wound healing and stromal matrix remodeling via binding to fibrotic molecules and their receptors,which provides bases for corneal diseases therapy and study of molecular mechanisms of corneal transparency.The bioactivities and the role of SLRPs in corneal transparency were reviewed in this article.

关 键 词：小分子亮氨酸重复蛋白聚糖 角膜混浊 角膜基质 胶原纤维 角膜创伤修复 

分 类 号：R772.2[医药卫生—眼科]