lncRNA与胃癌相关性的研究进展  

Research progress on the correlation between lncRNA and gastric cancer

作　　者：刘传绪 姚增武 鉴谧 胡金晨[2] 崔洪铭 于彬 赵扬[2] 姜立新[2] LIU Chuanxu;YAO Zengwu;JIAN Mi;HU Jinchen;CUI Hongming;YU Bin;ZHAO Yang;JIANG Lixin(Medical College of Qingdao University,Qingdao,Shandong 266000,P.R.China;The First Department of Gastrointestinal Surgery,Affiliated Yantai Yuhuangding Hospital of Qingdao University,Yantai,Shandong 264000,P.R.China)

机构地区：[1]青岛大学医学部,山东青岛266000 [2]青岛大学附属烟台毓璜顶医院胃肠外一科,山东烟台264000

出　　处：《中国普外基础与临床杂志》2022年第3期396-403,共8页Chinese Journal of Bases and Clinics In General Surgery

基　　金：山东大学项目(项目编号:3460019005);烟台市科技发展计划项目(项目编号:2019MSGY136)。

摘　　要：目的综述近年长链非编码RNA(long non-coding RNA,lncRNA)与胃癌的相关研究进展,并对今后的研究方向进行合理展望。方法收集国内外有关lncRNA与胃癌关系的文献,分类整理各种lncRNA文献,对lncRNA与胃癌的关系及作用机制进行深入解读,综述最新的研究进展。结果目前关于胃癌发生发展的分子机制尚没有完全阐明,但目前研究已表明lncRNA在表观遗传、转录、翻译、化学治疗耐药等多个层面均有调节作用,如H19、HOTTIP、UCA1、MEG3、MALAT1、HULC、HOTAIR、GAPLINC等,越来越多的lncRNA被发现与胃癌密切相关。结论lncRNA与胃癌的发生发展密切相关,可能是未来治疗胃癌的关键靶点。Objective To describe the research progress of long non-coding RNA(lncRNA)and gastric cancer in recent years,and to make reasonable prospect for future research direction.Method We collected a large amount of literatures on lncRNA and gastric cancer at home and abroad,and sort out various kinds of lncRNA,to make an in-depth interpretation of the relationship between lncRNA and gastric cancer and the mechanism of action,and then clarified the latest research progress.Results At present,the molecular mechanism of the occurrence and development of gastric cancer had not been fully elucidated,but current studies had shown that lncRNA(H19,HOTTIP,UCA1,MEG3,MALAT1,HULC,HOTAIR,GAPLINC,and so on)had regulatory effects at multiple levels such as epigenetics,transcription,translation,chemoresistance,and more and more lncRNA had been discovered closely related to gastric cancer.Conclusion lncRNA is closely related to the occurrence and development of gastric cancer and may be a key target for the treatment of gastric cancer in the future.

关 键 词：长链非编码RNA 胃癌 新辅助化学治疗 化学治疗耐药 

分 类 号：R735.2[医药卫生—肿瘤]