奥拉西坦药物对脑梗死恢复期患者轻度认知功能障碍的影响  

Effect of Olacetam on Mild Cognitive Impairment in Convalescent Patients with Cerebral Infarction

作　　者：徐莹 王博 李艳艳 XU Ying;WANG Bo;LI Yanyan(Department of Neurology,Chaoyang Central Hospital,Chaoyang 122000,China)

机构地区：[1]朝阳市中心医院神经内科,辽宁朝阳122000

出　　处：《中国医药指南》2022年第8期58-61,共4页Guide of China Medicine

摘　　要：目的针对将奥拉西坦药物应用于脑梗死恢复期轻度认知功能障碍临床治疗中的效果进行观察分析。方法本次试验经计算机随机法将医院2018年4月至2019年8月收治的120例脑梗死恢复期患者分为两组,各60例。两组均给予常规治疗,医师需根据患者的实际病情,引导其展开早期康复训练。观察组与对照组分别采取奥拉西坦药物与胞二磷胆碱药物治疗,对比两组患者的治疗效果。结果治疗前,两组患者在认知功能和生活质量两项评分上对比差异无统计学意义(P>0.05);治疗后,两组在认知功能和生活质量评分上差异有统计学意义,观察组评分均高于对照组(P<0.05);两组治疗总有效率比较差异有统计学意义,观察组相对较高(P<0.05)。和对照组相比,观察组治疗不良反应发生率较高且对比差异有统计学意义(P<0.05)。治疗前,两组患者SSS评分较为接近(P>0.05);观察组治疗后比对照组低,差异有统计学意义(P<0.05)。观察组与对照组治疗前Barthel评分对比,差异无统计学意义(P>0.05);观察组治疗后比对照组高,差异有统计学意义(P<0.05)。治疗前,两组白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)比较,差异无统计学意义(P>0.05);治疗后,观察组比对照组低(P<0.05)。结论对脑梗死恢复期患者采取奥拉西坦药物治疗有利于提升患者的认知功能和日常生活能力,改善其神经功能缺损状况。Objective To observe the effect of Oxiracetam on patients with mild cognitive impairment in convalescent stage of cerebral infarction.Methods A total of 120 convalescent patients with cerebral infarction treated.Randomized in hospital from April 2018 to August 2019 two groups with 60 cases in each group.Both groups were given routine treatment.Doctors need to guide patients to carry out early rehabilitation training according to their actual condition.The observation group and the control group were treated with oxiracetam and citicoline respectively,and the therapeutic effects of the two groups were compared.Results Before treatment,there was no difference between the two groups in the scores of cognitive function and quality of life(P>0.05).After treatment,there were significant differences in cognitive function and quality of life scores between the two groups,and the scores in the observation group were higher than those in the control group(P<0.05).Compared with the control group,the incidence of adverse reactions in the observation group was higher and the difference was significant(P<0.05).Before treatment,the SSS scores of the two groups were relatively close(P>0.05).The observation group was lower than the control group after treatment,and the difference was statistically significant(P<0.05).There was no difference in Barthel score between the observation group and the control group before treatment(P>0.05).The observation group was higher than the control group after treatment,and the difference was statistically significant(P<0.05).Before treatment,interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α),the difference was not statistically significant(P>0.05).After treatment,the observation group was lower than the control group(P<0.05).Conclusion Oxiracetam treatment for convalescent patients with cerebral infarction is helpful to improve their cognitive function and ability of daily living,and improve their neurological deficit.

关 键 词：脑梗死恢复期 轻度认知功能障碍 药物治疗 认知功能 神经功能缺损 日常生活能力 

分 类 号：R743.33[医药卫生—神经病学与精神病学]